New homoisoflavonoid analogues protect cells by regulating autophagy

• Published in: Bioorganic & medicinal chemistry letters Vol. 27; no. 6; pp. 1441 - 1445
• Main Authors: Gan, Li-She, Zeng, Lin-Wei, Li, Xiang-Rong, Zhou, Chang-Xin, Li, Jie
• Format: Journal Article
• Language: English
• Published: OXFORD Elsevier Ltd 15.03.2017; Elsevier
• Subjects: Autophagy; Autophagy - drug effects; Cardioprotection; Cell Line, Tumor; Chemistry; Chemistry, Medicinal; Chemistry, Organic; Cytoprotection - drug effects; Flavonoids - pharmacology; Homoisoflavonoid; Humans; Life Sciences & Biomedicine; Neuroprotection; Pharmacology & Pharmacy; Physical Sciences; Science & Technology; Synthesis; Homoisoflavonoid; Neuroprotection; Synthesis; Cardioprotection; Autophagy; OPHIOPOGON-JAPONICUS

A series of homoisoflavonoid derivatives were designed and synthesized for the development of drug candidates for cell protective activities. [Display omitted] As a special group of naturally occurring flavonoids, homoisoflavonoids have been discovered as active components of several traditional Chi...