Insights into IL-1 family cytokines in kidney allograft transplantation: IL-18BP and free IL-18 as emerging biomarkers

• Published in: Cytokine (Philadelphia, Pa.) Vol. 180; p. 156660
• Main Authors: Cecrdlova, E., Krupickova, L., Fialova, M., Novotny, M., Tichanek, F., Svachova, V., Mezerova, K., Viklicky, O., Striz, I.
• Format: Journal Article
• Language: English
• Published: England Elsevier Ltd 01.08.2024
• Subjects: Acute rejection; Adult; Allograft; Allografts; Biomarkers - blood; Cytokines; Female; Graft Rejection - blood; Graft Rejection - immunology; Humans; IL-1 family; Intercellular Signaling Peptides and Proteins - blood; Interleukin-1 - blood; Interleukin-18 - blood; Kidney; Kidney Transplantation; Male; Middle Aged; Prospective Studies; Transplantation; Transplantation, Homologous - methods; eGFR; LOD; Acute rejection; DGF; Cytokines; MMF; IVIG; Transplantation; Kidney; CS; AR; DSA; ATG; PE; Tac; IL-1 family; ABMR; mTOR; Allograft; HLA; PRA

[Display omitted] •Serum levels of the proinflammatory IL-1beta, IL-18, and IL-36beta are downregulated after kidney transplantation.•Concentrations of calculated free IL-18 and IL-18BP are increased at the time of acute rejection.•Serum IL-18BP concentrations may be partially affected by kidney fun...