Nanodesign of new self-assembling core-shell gellan-transfersomes loading baicalin and in vivo evaluation of repair response in skin

• Published in: Nanomedicine Vol. 14; no. 2; pp. 569 - 579
• Main Authors: Manconi, Maria, Manca, Maria Letizia, Caddeo, Carla, Valenti, Donatella, Cencetti, Claudia, Diez-Sales, Octavio, Nacher, Amparo, Mir-Palomo, Silvia, Terencio, Maria Carmen, Demurtas, Davide, Gomez-Fernandez, Juan Carmelo, Aranda, Francisco José, Fadda, Anna Maria, Matricardi, Pietro
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 01.02.2018
• Subjects: Administration, Cutaneous; Animals; Animals, Newborn; Anti-Inflammatory Agents, Non-Steroidal - administration & dosage; Anti-Inflammatory Agents, Non-Steroidal - chemistry; Drug Delivery Systems; Female; Flavonoids - administration & dosage; Flavonoids - chemistry; Gellan; In vivo studies; Inflammation - drug therapy; Liposomes - chemistry; Mice; Nanoparticles - chemistry; Polysaccharides, Bacterial - chemistry; Rheological studies; SAXS analysis; Skin - drug effects; Skin - injuries; Skin Absorption; Skin delivery; Swine; Transfersomes; Wound Healing - drug effects; Transfersomes; Gellan; SAXS analysis; Rheological studies; Skin delivery; In vivo studies

Gellan nanohydrogel and phospholipid vesicles were combined to incorporate baicalin in new self-assembling core-shell gellan-transfersomes obtained by an easy, scalable method. The vesicles were small in size (~107 nm) and monodispersed (P.I. ≤ 0.24), forming a viscous system (~24 mPa/s) as compared...