Spontaneous antibody production caused by regulatory T cell deficiency occurs through a germinal center-independent pathway

• Published in: Biochemical and biophysical research communications Vol. 527; no. 4; pp. 909 - 914
• Main Authors: Tai, Yuki, Takano, Azumi, Haga, Katsura, Koshida, Kouhei, Harada, Yohsuke
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 05.07.2020
• Subjects: Allergy; Animals; Antibody; Antibody Formation; Autoimmunity; Forkhead Transcription Factors - genetics; Forkhead Transcription Factors - immunology; Germinal center; Germinal Center - immunology; Humoral immune response; Immunoglobulin E - immunology; Immunoglobulin G - immunology; Mice, Inbred C57BL; Mice, Knockout; Regulatory T cell deficiency; T-Lymphocytes, Regulatory - immunology; Autoimmunity; Humoral immune response; Allergy; Regulatory T cell deficiency; Antibody; Germinal center

Foxp3+ regulatory T cells (Tregs) are essential for the prevention of autoantibody and allergen-specific IgE production. Treg deficiency causes an elevation of the serum levels of these pathogenic antibodies, accompanied by spontaneous germinal center (GC) formation. However, it remains to be determ...