Spontaneous antibody production caused by regulatory T cell deficiency occurs through a germinal center-independent pathway

Foxp3+ regulatory T cells (Tregs) are essential for the prevention of autoantibody and allergen-specific IgE production. Treg deficiency causes an elevation of the serum levels of these pathogenic antibodies, accompanied by spontaneous germinal center (GC) formation. However, it remains to be determ...

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Bibliographic Details
Published inBiochemical and biophysical research communications Vol. 527; no. 4; pp. 909 - 914
Main Authors Tai, Yuki, Takano, Azumi, Haga, Katsura, Koshida, Kouhei, Harada, Yohsuke
Format Journal Article
LanguageEnglish
Published United States Elsevier Inc 05.07.2020
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