Epstein–Barr Virus Induces Adipocyte Dedifferentiation to Modulate the Tumor Microenvironment

• Published in: Cancer research (Chicago, Ill.) Vol. 81; no. 12; pp. 3283 - 3294
• Main Authors: Liu, Shu-Chen, Tsang, Ngan-Ming, Lee, Po-Ju, Sui, Yun-Hua, Huang, Chen-Han, Liu, Tzu-Tung
• Format: Journal Article
• Language: English
• Published: United States 15.06.2021
• Subjects: Adipocytes - pathology; Adipocytes - virology; Cell Dedifferentiation; Epstein-Barr Virus Infections - complications; Epstein-Barr Virus Infections - immunology; Epstein-Barr Virus Infections - virology; Female; Herpesvirus 4, Human - isolation & purification; Humans; Male; Middle Aged; Nasopharyngeal Carcinoma - immunology; Nasopharyngeal Carcinoma - pathology; Nasopharyngeal Carcinoma - virology; Nasopharyngeal Neoplasms - immunology; Nasopharyngeal Neoplasms - pathology; Nasopharyngeal Neoplasms - virology; Tumor Microenvironment; Virus Activation; Virus Replication

The most frequent location of metastatic EBV+ nasopharyngeal carcinoma (NPC) is the bone marrow, an adipocyte-dominant region. Several EBV-associated lymphoepithelioma-like carcinoma (LELC) types also grow in the anatomical vicinity of fat tissues. Here we show that in an adipose tissue-rich tumor s...