Novel cytosensor for accurate detection of circulating tumor cells based on a dual-recognition strategy and BSA@Ag@Ir metallic-organic nanoclusters

• Published in: Biosensors & bioelectronics Vol. 179; p. 113102
• Main Authors: Shen, Huawei, Liu, Liyu, Yuan, Zuowei, Liu, Qian, Li, Baiying, Zhang, Ming, Tang, Hejun, Zhang, Juan, Zhao, Shiqiao
• Format: Journal Article
• Language: English
• Published: England Elsevier B.V 01.05.2021
• Subjects: Biosensing Techniques; Circulating tumor cells; Cytosensor; DNA proximity Effect; Dual recognition; Gold; Humans; Metal Nanoparticles; Metallic organic nanoclusters; Neoplastic Cells, Circulating; Silver; Dual recognition; DNA proximity Effect; Circulating tumor cells; Cytosensor; Metallic organic nanoclusters

Herein, based on a dual-recognition strategy and BSA@Ag@Ir metallic-organic nanoclusters (BSA@Ag@Ir MONs), a highly specific and sensitive cytosensor was developed for detecting circulating tumor cells (CTCs). To amplify current signal, novel BSA@Ag@Ir MONs with outstanding catalytic activity and hu...