S-CMC-Lys-dependent stimulation of electrogenic glutathione secretion by human respiratory epithelium

• Published in: Journal of molecular medicine (Berlin, Germany) Vol. 84; no. 1; pp. 97 - 107
• Main Authors: GUIZZARDI, F, RODIGHIERO, S, DAFFONCHIO, L, NOVELLINI, R, PAULMICHL, M, MEYER, G, BINELLI, A, SAINO, S, BONONI, E, DOSSENA, S, GARAVAGLIA, M. L, BAZZINI, C, BOBTA, G, CONESE, M
• Format: Journal Article
• Language: English
• Published: Berlin Springer 2006; Springer Nature B.V
• Subjects: Biological and medical sciences; Carbocysteine - analogs & derivatives; Carbocysteine - pharmacology; Cell Line; Chlorides - metabolism; Cystic Fibrosis Transmembrane Conductance Regulator - genetics; Cystic Fibrosis Transmembrane Conductance Regulator - metabolism; General aspects; Glutathione - secretion; Humans; Medical sciences; Patch-Clamp Techniques; Respiratory Mucosa - cytology; Respiratory Mucosa - drug effects; Respiratory Mucosa - metabolism; Delivery system; Human; CFTR protein; Respiratory epithelium; Secretion; Patch-clamp techniques; Ions; Stimulation; Ionic channel; Antioxidant; Organic sulfide; Carbocisteine; Protein; Medicine; Antioxidants; Mucolytic; Dosage form; Ion channels; Technique; Cystic fibrosis transmembrane conductance regulator; Patch; S-carbocysteine-Lys; Glutathione; Skin test

Glutathione (GSH) is one of the most important defense mechanisms against oxidative stress in the respiratory epithelial lining fluid. Considering that GSH secretion in respiratory cells has been postulated to be at least partially electrogenic, and that the mucoregulator S-carbocysteine lysine salt...