Dissecting Secondary Immunodeficiency: Identification of Primary Immunodeficiency within B-Cell Lymphoproliferative Disorders

• Published in: Journal of clinical immunology Vol. 45; no. 1; p. 32
• Main Authors: Palacios-Ortega, María, Guerra-Galán, Teresa, Jiménez-Huete, Adolfo, García-Aznar, José María, Pérez-Guzmán, Marc, Mansilla-Ruiz, Maria Dolores, Mendiola, Ángela Villegas, López, Cristina Pérez, Hornero, Elsa Mayol, Rodriguez, Alejandro Peixoto, Cortijo, Ascensión Peña, Polo Zarzuela, Marta, Morales, Marta Mateo, Mandly, Eduardo Anguita, Cárdenas, Maria Cruz, Carrero, Alejandra, García, Carlos Jiménez, Bolaños, Estefanía, Íñigo, Belén, Medina, Fiorella, de la Fuente, Eduardo, Ochoa-Grullón, Juliana, García-Solís, Blanca, García-Carmona, Yolanda, Fernández-Arquero, Miguel, Benavente-Cuesta, Celina, de Diego, Rebeca Pérez, Rider, Nicholas, Sánchez-Ramón, Silvia
• Format: Journal Article
• Language: English
• Published: New York Springer US 01.12.2025; Springer Nature B.V
• Subjects: Adolescent; Adult; B-Lymphocytes - immunology; Biomedical and Life Sciences; Biomedicine; Cell differentiation; Child; Child, Preschool; Children; Diagnosis, Differential; Female; Humans; Hypogammaglobulinemia; Immune system; Immunodeficiency; Immunologic Deficiency Syndromes - diagnosis; Immunologic Deficiency Syndromes - immunology; Immunological memory; Immunology; Immunoproliferative diseases; Infant; Infections; Infectious Diseases; Internal Medicine; Lymphatic diseases; Lymphocytes; Lymphocytes B; Lymphoproliferative Disorders - diagnosis; Lymphoproliferative Disorders - etiology; Lymphoproliferative Disorders - immunology; Male; Medical Microbiology; Memory cells; Patients; Primary immunodeficiencies; Primary Immunodeficiency Diseases - diagnosis; Primary Immunodeficiency Diseases - etiology; Primary Immunodeficiency Diseases - immunology; Statistical analysis; B cell chronic lymphoproliferative disorders, secondary immunodeficiency; Primary immunodeficiencies; Clinical diagnosis; Artificial intelligence; Early detection

Distinguishing between primary (PID) and secondary (SID) immunodeficiencies, particularly in relation to hematological B-cell lymphoproliferative disorders (B-CLPD), poses a major clinical challenge. We aimed to analyze and define the clinical and laboratory variables in SID patients associated with...