Applications of Dendrimers in Nanomedicine and Drug Delivery: A Review

Dendrimers are hyper-branched organic compounds characterized via a three-dimensional structure possessing functional groups on the surface. These terminals groups can be simply modified to enhance the functionality of dendrimers and produce biocompatible and versatile products. They are a promising...

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Published in	Journal of inorganic and organometallic polymers and materials Vol. 31; no. 6; pp. 2246 - 2261
Main Authors	Nikzamir, Mohammad, Hanifehpour, Younes, Akbarzadeh, Abolfazl, Panahi, Yunes
Format	Journal Article
Language	English
Published	New York Springer US 01.06.2021 Springer Nature B.V
Subjects	Biocompatibility Chemical compounds Chemistry Chemistry and Materials Science Dendrimers Drug delivery systems Functional groups Inorganic Chemistry Organic Chemistry Organic compounds Pharmacology Polymer Sciences Synthesis Topical Reviews Toxicity Dendrimer Drug delivery PAMAM dendrimer Nanomedicine Dendritic structure
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Abstract	Dendrimers are hyper-branched organic compounds characterized via a three-dimensional structure possessing functional groups on the surface. These terminals groups can be simply modified to enhance the functionality of dendrimers and produce biocompatible and versatile products. They are a promising agent for nanomedicine applications because of their unique properties, including nanoscale size, globular shape, and high reactivity, solubility in water, internal cavities, and comfortable synthesis methods. The use of dendrimers as drug delivery systems have received great attention from researchers. Dendrimers can be applied as carriers for different therapeutic agents. They can reduce the toxicity of drugs and increase their efficacy. This review provides a general outline of the structure and types of dendrimers, the synthesis of dendrimers, and applications in the nanomedicine field with emphasis on drug delivery.
AbstractList	Dendrimers are hyper-branched organic compounds characterized via a three-dimensional structure possessing functional groups on the surface. These terminals groups can be simply modified to enhance the functionality of dendrimers and produce biocompatible and versatile products. They are a promising agent for nanomedicine applications because of their unique properties, including nanoscale size, globular shape, and high reactivity, solubility in water, internal cavities, and comfortable synthesis methods. The use of dendrimers as drug delivery systems have received great attention from researchers. Dendrimers can be applied as carriers for different therapeutic agents. They can reduce the toxicity of drugs and increase their efficacy. This review provides a general outline of the structure and types of dendrimers, the synthesis of dendrimers, and applications in the nanomedicine field with emphasis on drug delivery.
Author	Panahi, Yunes Nikzamir, Mohammad Hanifehpour, Younes Akbarzadeh, Abolfazl
Author_xml	– sequence: 1 givenname: Mohammad surname: Nikzamir fullname: Nikzamir, Mohammad organization: Pharmacotherapy Department, Faculty of Pharmacy, Bagyattallah University of Medical Sciences – sequence: 2 givenname: Younes surname: Hanifehpour fullname: Hanifehpour, Younes organization: Department of Chemistry, Sayyed Jamaleddin Asadabadi University – sequence: 3 givenname: Abolfazl surname: Akbarzadeh fullname: Akbarzadeh, Abolfazl organization: Stem Cell Research Center, Tabriz University of Medical Sciences – sequence: 4 givenname: Yunes surname: Panahi fullname: Panahi, Yunes email: yunespanahi@yahoo.com organization: Pharmacotherapy Department, Faculty of Pharmacy, Bagyattallah University of Medical Sciences, Department of Chemistry, Sayyed Jamaleddin Asadabadi University
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Snippet	Dendrimers are hyper-branched organic compounds characterized via a three-dimensional structure possessing functional groups on the surface. These terminals...
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SubjectTerms	Biocompatibility Chemical compounds Chemistry Chemistry and Materials Science Dendrimers Drug delivery systems Functional groups Inorganic Chemistry Organic Chemistry Organic compounds Pharmacology Polymer Sciences Synthesis Topical Reviews Toxicity
Title	Applications of Dendrimers in Nanomedicine and Drug Delivery: A Review
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