Identification of monoclonal antibody variants involved in aggregate formation – Part 1: Charge variants

• Published in: European journal of pharmaceutics and biopharmaceutics Vol. 158; pp. 123 - 131
• Main Authors: Meyer, Robina M., Berger, Lukas, Nerkamp, Joerg, Scheler, Stefan, Nehring, Sebastian, Friess, Wolfgang
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier B.V 01.01.2021
• Subjects: Differential scanning fluorimetry; FPLC; Light scattering; mAb charge variants; Protein aggregation; Protein stability; FPLC; Protein stability; Protein aggregation; Differential scanning fluorimetry; mAb charge variants; Light scattering

[Display omitted] Biopharmaceutical products contain conformational and chemical variants, that are typically well characterized regarding identity and activity. However, little is known about their self-interaction propensity and tendency to unfold, which are critical characteristics for drug stabi...