Uncovering novel exosome-specific miRNA markers and potential molecular mechanisms in autoimmune pancreatitis

• Published in: Genomics (San Diego, Calif.) Vol. 117; no. 4; p. 111068
• Main Authors: Lai, Yamin, Shang, Mengmeng, Yang, Hong, Lv, Hong, Zhang, Panpan, Guo, Tao, Zhang, Wen, Yang, Aiming, Yu, Jia, Qian, Jiaming, Wu, Dong
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 01.07.2025
• Subjects: Autoimmune pancreatitis; Autoimmune Pancreatitis - genetics; Autoimmune Pancreatitis - metabolism; Biomarkers - metabolism; Exosome; Exosomes - genetics; Exosomes - metabolism; Female; Gene Regulatory Networks; Hsa-miR-30b-5p; Humans; Immune; Male; MicroRNAs - genetics; MicroRNAs - metabolism; Middle Aged; Pancreatic Neoplasms - genetics; RNA, Long Noncoding - genetics; RNA, Long Noncoding - metabolism; RNA, Messenger - genetics; RNA, Messenger - metabolism; Target genes; Transcription Factors - genetics; Transcription Factors - metabolism; Target genes; Exosome; Autoimmune pancreatitis; Hsa-miR-30b-5p; Immune

Autoimmune pancreatitis (AIP) is a rare disease and sometimes difficult to make a diagnosis. This study aimed to identify exosomal miRNAs that could serve as novel biomarkers of type 1 AIP. We extracted miRNAs from the exosomes of patients with AIP, chronic pancreatitis (CP), pancreatic cancer, and...