Atorvastatin plus pravastatin for the treatment of heterozygous familial hypercholesterolaemia: A pilot study

• Published in: Current medical research and opinion Vol. 17; no. 4; pp. 267 - 272
• Main Authors: ATHYROS, Vasilios G, PAPAGEORGIOU, Athanasios A, DEMITRIADIS, Dimokritos S, KONTOPOULOS, Athanasios G
• Format: Journal Article
• Language: English
• Published: Reading Librapharm 01.01.2001; Informa Healthcare
• Subjects: Analysis of Variance; Anticholesteremic Agents - therapeutic use; Atorvastatin Calcium; Biological and medical sciences; Drug Therapy, Combination; Female; General and cellular metabolism. Vitamins; Heptanoic Acids - therapeutic use; Humans; Hyperlipoproteinemia Type II - drug therapy; Male; Medical sciences; Middle Aged; Pharmacology. Drug treatments; Pilot Projects; Pravastatin - therapeutic use; Prospective Studies; Pyrroles - therapeutic use; Treatment Outcome; Human; Drug combination; Enzyme; Enzyme inhibitor; Metabolic diseases; Lipids; Hyperlipoproteinemia; Statin derivative; Pravastatin; Chemotherapy; Familial disease; Hypercholesterolemia; Treatment; Atorvastatin; Hydroxymethylglutaryl-CoA reductase; Oxidoreductases; Dyslipemia; Antilipemic agent

The most common side-effect of statins, mainly during dose titration, is liver toxicity, In these cases, sufficient control of low density lipoprotein cholesterol (LDL-C) in patients with heterozygous familial hypercholesterolaemia (HFH) becomes problematical. In patients with intolerance to resins...