Antibody-mediated delivery of chimeric protein degraders which target estrogen receptor alpha (ERα) - Dragovich, Peter S.; Adhikari, Pragya; Blake, Robert A.; Blaquiere, Nicole; Chen, Jinhua; Cheng, Yun-Xing; den Besten, Willem; Han, Jinping; Hartman, Steven J.; He, Jintang; He, Mingtao; Rei Ingalla, Ellen; et al. (Bioorganic & medicinal chemistry letters, 2020)
Keywords: Antibodies, Monoclonal - chemistry; Antibodies, Monoclonal - immunology; Antibody-drug conjugates; Antineoplastic Agents - chemistry; Antineoplastic Agents - immunology; Antineoplastic Agents - pharmacology; Chimeric protein degraders; Drug Carriers - chemistry; Drug delivery; Drug Design; Estrogen receptor; Estrogen Receptor alpha - immunology; Estrogen Receptor alpha - metabolism; Humans; Immunoconjugates - chemistry; Immunoconjugates - immunology; Immunoconjugates - pharmacology; MCF-7 Cells; Proteolysis - drug effects; Receptor, ErbB-2 - metabolism; Estrogen receptor; Drug delivery; Chimeric protein degraders; Antibody-drug conjugates