Discovery of noscapine derivatives as potential β-tubulin inhibitors

• Published in: Bioorganic & medicinal chemistry letters Vol. 30; no. 20; pp. 127489 - 127493
• Main Authors: Nemati, Faezeh, Salehi, Peyman, Bararjanian, Morteza, Hadian, Nasim, Mohebbi, Maryam, Lauro, Gianluigi, Ruggiero, Dafne, Terracciano, Stefania, Bifulco, Giuseppe, Bruno, Ines
• Format: Journal Article
• Language: English
• Published: OXFORD Elsevier Ltd 15.10.2020; Elsevier
• Subjects: Chemistry; Chemistry, Medicinal; Chemistry, Organic; Huisgen reaction; Life Sciences & Biomedicine; Noscapine; Pharmacology & Pharmacy; Physical Sciences; Science & Technology; Surface plasmon resonance; Triazole; Tubulin; Triazole; Surface plasmon resonance; Tubulin; Noscapine; Huisgen reaction; CELLS; PERTURB MITOSIS; MICROTUBULE; ANALOGS; AGENTS

[Display omitted] •Twenty novel 1,2,3-triazole noscapine derivatives were synthesized.•Selected triazoles exhibited lower cell viability compared with noscapine.•Two promising compounds (8h and 9c) were identified.•The cytotoxicity was supposed to be correlated with tubulin affinity. Twenty novel 1,...