Maternal prepregnancy overweight and obesity and the risk of preeclampsia: A meta-analysis of cohort studies
•The site selection of included studies was extensive.•Location of study in statistical models may be the source of heterogeneity.•Prepregnancy maternal overweight and obesity is a risk factor for preeclampsia. The aim of our meta-analysis was to explore whether overweight and obesity was associated...
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Published in | Obesity research & clinical practice Vol. 14; no. 1; pp. 27 - 33 |
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Main Authors | , , |
Format | Journal Article |
Language | English |
Published |
Netherlands
Elsevier Ltd
01.01.2020
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Subjects | |
Online Access | Get full text |
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Summary: | •The site selection of included studies was extensive.•Location of study in statistical models may be the source of heterogeneity.•Prepregnancy maternal overweight and obesity is a risk factor for preeclampsia.
The aim of our meta-analysis was to explore whether overweight and obesity was associated with preeclampsia or not.
Three databases were systematically reviewed and reference lists of relevant articles were checked. Meta-analysis of published cohort studies comparing whether overweight and obesity was associated with preeclampsia and adjusting for potential confounding factors. Calculations of pooled estimates were conducted in random-effects models. Heterogeneity was tested by using Chi-square test with Cochrane and heterogeneity was explored with meta-regression. Publication bias was estimated from Egger’s test (linear regression method) and Begg’s test (rank correlation method).
Nineteen studies met the inclusion criteria. The meta-analysis showed that overweight and obesity was associated with an increased risk of preeclampsia. The aOR calculated for 13 studies (compared overweight to normal weight) was 1.71, 95% CI (1.52, 1.91) for random-effects models and 19 studies (compared obesity to normal weight) was 2.48, 95% CI (2.05, 2.90) for random-effects models, stratified analyses showed no differences regarding quality grade, location of study and period of anthropometric measurement. There was no indication of a publication bias either from the result of Egger’s test or Begg’s test.
Our results suggested that prepregnancy maternal overweight and obesity are significantly associated with an increased risk of preeclampsia. |
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Bibliography: | ObjectType-Article-2 SourceType-Scholarly Journals-1 ObjectType-Feature-1 content type line 23 ObjectType-Undefined-3 |
ISSN: | 1871-403X 1878-0318 |
DOI: | 10.1016/j.orcp.2020.01.004 |