Decompression of keratocystic odontogenic tumors leading to increased fibrosis, but without any change in epithelial proliferation

• Published in: Oral surgery, oral medicine, oral pathology and oral radiology Vol. 123; no. 6; pp. 634 - 644
• Main Authors: Awni, Sarah, Conn, Brendan
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 01.06.2017
• Subjects: Adolescent; Adult; Aged; Biomarkers - metabolism; Cell Proliferation; Child; Decompression, Surgical; Dentistry; Epithelium - pathology; Female; Fibrosis - pathology; Humans; Immunohistochemistry; Ki-67 Antigen - metabolism; Male; Middle Aged; Odontogenic Tumors - metabolism; Odontogenic Tumors - pathology; Odontogenic Tumors - surgery; Proto-Oncogene Proteins c-bcl-2 - metabolism; Retrospective Studies; Tumor Suppressor Protein p53 - metabolism

The aim of this study was to investigate whether decompression treatment induces changes in the histology or biologic behavior of keratocystic odontogenic tumor (KCOT). Seventeen patients with KCOT underwent decompression treatment with or without enucleation. Histologic evaluation and immunohistoch...