Impact of CCL4 gene polymorphisms and environmental factors on oral cancer development and clinical characteristics

• Published in: Oncotarget Vol. 8; no. 19; pp. 31424 - 31434
• Main Authors: Lien, Ming-Yu, Lin, Chiao-Wen, Tsai, Hsiao-Chi, Chen, Yng-Tay, Tsai, Ming-Hsui, Hua, Chun-Hung, Yang, Shun-Fa, Tang, Chih-Hsin
• Format: Journal Article
• Language: English
• Published: United States Impact Journals LLC 09.05.2017
• Subjects: Adult; Aged; Alleles; Case-Control Studies; Chemokine CCL4 - genetics; Environment; Female; Gene-Environment Interaction; Genetic Predisposition to Disease; Genotype; Humans; Linkage Disequilibrium; Male; Middle Aged; Mouth Neoplasms - etiology; Mouth Neoplasms - genetics; Mouth Neoplasms - pathology; Neoplasm Grading; Neoplasm Metastasis; Neoplasm Staging; Odds Ratio; Polymorphism, Single Nucleotide; Research Paper; single-nucleotide polymorphism; oral cancer; CCL4

In Taiwan, oral cancer has causally been associated with environmental carcinogens. CCL4 (C-C chemokine ligand 4), a macrophage inflammatory protein with a key role in inflammation and immune-regulation, was implicated in carcinogenesis by facilitating instability in the tumor environment. The purpo...