Dermal Capillary Clearance: Physiology and Modeling

• Published in: Skin pharmacology and physiology Vol. 18; no. 2; pp. 55 - 74
• Main Authors: Kretsos, K., Kasting, G.B.
• Format: Journal Article
• Language: English
• Published: Basel, Switzerland S. Karger AG 01.03.2005
• Subjects: Administration, Cutaneous; Animals; Capillaries - drug effects; Capillaries - physiology; Cell Membrane Permeability - drug effects; Dermis - blood supply; Dermis - drug effects; Humans; Metabolic Clearance Rate; Models, Biological; Review; Dermis; Clearance; Permeability; Lymphatics; Capillaries; Modeling

Substances applied to the skin surface may permeate deeper tissue layers and pass into the body’s systemic circulation by entering blood or lymphatic vessels in the dermis. The purpose of this review is an in-depth analysis of the dermal clearance/exchange process and its constituents: transport thr...