The Cardioprotective Effect of Vitamin D in Breast Cancer Patients Receiving Adjuvant Doxorubicin Based Chemotherapy

• Published in: Clinical breast cancer Vol. 22; no. 4; pp. 359 - 366
• Main Authors: El-Bassiouny, Noha A., Helmy, Maged W., Hassan, Mostafa Alaa Eldin, Khedr, Gehan A.
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 01.06.2022
• Subjects: Antineoplastic Combined Chemotherapy Protocols - adverse effects; Breast cancer; Breast Neoplasms - drug therapy; Breast Neoplasms - etiology; Cardio toxicity; Chemotherapy, Adjuvant - adverse effects; Cyclophosphamide - adverse effects; Doxorubicin; Female; Humans; Interleukin-6 - therapeutic use; Vitamin D; Vitamin D - therapeutic use; Vitamins; Vit D; LVEF; Breast cancer; DOX; Doxorubicin; TNF; IL-6; LDH; Vitamin D; ROS; cTnT; TNBC; Cardio toxicity; DIC

•Vitamin D may have cardioprotective effect.•Vitamin D has add-on value in breast cancer patients receiving doxorubicin-based chemotherapy.•Vitamin D reduced Doxorubicin induced cardiotoxicity.•The cardioprotective effects of Vit D may be attributed to the ability of Vit D to decrease the pro-inflam...