MicroRNA-183-3p up-regulated by vagus nerve stimulation mitigates chronic systolic heart failure via the reduction of BNIP3L-mediated autophagy

• Published in: Gene Vol. 726; p. 144136
• Main Authors: Ouyang, Shao, Chen, Wei, Zeng, Gaofeng, Lei, Changcheng, Tian, Guoping, Zhu, Mingyan, Liu, Yang, Yang, Min
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier B.V 05.02.2020
• Subjects: Animals; Autophagy; Autophagy - genetics; Bcl-2 interacting protein 3 like; Chronic systolic heart failure; Down-Regulation - genetics; Heart Failure, Systolic - genetics; Male; Membrane Proteins - genetics; MicroRNAs - genetics; miR-183-3p; Proto-Oncogene Proteins - genetics; Rats; Rats, Wistar; Stroke Volume - genetics; Transcriptional Activation - genetics; Up-Regulation - genetics; Vagus nerve stimulation; Vagus Nerve Stimulation - methods; Ventricular Function, Left - genetics; CSHF; Chronic systolic heart failure; FBS; ECG; miRNA; Vagus nerve stimulation; VNS; Bcl-2 interacting protein 3 like; SO; miR-183-3p; Autophagy

•miR-183-3p directly targeted BNIP3L in rats.•miR-183-3p Regulates autophagy via the mTOR/Akt pathway. Chronic systolic heart failure (CSHF) was a complex syndrome. Recently, vagus nerve stimulation (VNS), a novel treatment method, has emerged for the treatment of CSHF. therefore the aim of this stu...