Sequential changes in von Willebrand factor and soluble thrombomodulin in acute ischemic stroke
The purposes of the present study were to investigate sequential changes in plasma von Willebrand factor (vWf) activities and serum soluble thrombomodulin (sTM) concentrations, compared with white blood cell (WBC) counts, and to disclose the different roles of vWf and sTM in acute ischemic stroke. F...
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Published in | Journal of stroke and cerebrovascular diseases Vol. 10; no. 6; pp. 257 - 264 |
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Main Authors | , , , , |
Format | Journal Article |
Language | English |
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United States
Elsevier Inc
01.11.2001
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Abstract | The purposes of the present study were to investigate sequential changes in plasma von Willebrand factor (vWf) activities and serum soluble thrombomodulin (sTM) concentrations, compared with white blood cell (WBC) counts, and to disclose the different roles of vWf and sTM in acute ischemic stroke. Forty-three acute ischemic stroke patients admitted to our hospital within 48 hours from onset were enrolled. Plasma vWf activities, serum sTM concentrations, and WBC counts were measured at the acute stage and 1 and 6 months after admission. The time course study revealed that vWf activities increased more markedly 1 month after admission than at the acute stage. However, sTM concentrations were low at the acute stage and increased sequentially at 1 month (not significantly) and 6 months (significantly) after admission. In contrast, elevated WBC counts at the acute stage decreased significantly at 1 and 6 months after admission. Raised vWf activities 1 month after admission were suggested to occur through continuous endothelial dysfunction or repair and platelet activation, compared with the acute stage, and decreased sTM at the acute stage through down-regulation of sTM synthesis by acute inflammatory response after acute ischemic stroke, compared with the chronic stage. Copyright © 2001 by National Stroke Association |
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AbstractList | The purposes of the present study were to investigate sequential changes in plasma von Willebrand factor (vWf) activities and serum soluble thrombomodulin (sTM) concentrations, compared with white blood cell (WBC) counts, and to disclose the different roles of vWf and sTM in acute ischemic stroke. Forty-three acute ischemic stroke patients admitted to our hospital within 48 hours from onset were enrolled. Plasma vWf activities, serum sTM concentrations, and WBC counts were measured at the acute stage and 1 and 6 months after admission. The time course study revealed that vWf activities increased more markedly 1 month after admission than at the acute stage. However, sTM concentrations were low at the acute stage and increased sequentially at 1 month (not significantly) and 6 months (significantly) after admission. In contrast, elevated WBC counts at the acute stage decreased significantly at 1 and 6 months after admission. Raised vWf activities 1 month after admission were suggested to occur through continuous endothelial dysfunction or repair and platelet activation, compared with the acute stage, and decreased sTM at the acute stage through down-regulation of sTM synthesis by acute inflammatory response after acute ischemic stroke, compared with the chronic stage. The purposes of the present study were to investigate sequential changes in plasma von Willebrand factor (vWf) activities and serum soluble thrombomodulin (sTM) concentrations, compared with white blood cell (WBC) counts, and to disclose the different roles of vWf and sTM in acute ischemic stroke. Forty-three acute ischemic stroke patients admitted to our hospital within 48 hours from onset were enrolled. Plasma vWf activities, serum sTM concentrations, and WBC counts were measured at the acute stage and 1 and 6 months after admission. The time course study revealed that vWf activities increased more markedly 1 month after admission than at the acute stage. However, sTM concentrations were low at the acute stage and increased sequentially at 1 month (not significantly) and 6 months (significantly) after admission. In contrast, elevated WBC counts at the acute stage decreased significantly at 1 and 6 months after admission. Raised vWf activities 1 month after admission were suggested to occur through continuous endothelial dysfunction or repair and platelet activation, compared with the acute stage, and decreased sTM at the acute stage through down-regulation of sTM synthesis by acute inflammatory response after acute ischemic stroke, compared with the chronic stage. Copyright © 2001 by National Stroke Association |
Author | Nakamura, Shigenobu Kohriyama, Tatsuo Kozuka, Kazuko Nomura, Eiichi Kajikawa, Hiroshi |
Author_xml | – sequence: 1 givenname: Eiichi surname: Nomura fullname: Nomura, Eiichi organization: Department of Neurology, Suiseikai Kajikawa Hospital – sequence: 2 givenname: Tatsuo surname: Kohriyama fullname: Kohriyama, Tatsuo organization: Third Department of Internal Medicine, Hiroshima University School of Medicine – sequence: 3 givenname: Kazuko surname: Kozuka fullname: Kozuka, Kazuko organization: Third Department of Internal Medicine, Hiroshima University School of Medicine – sequence: 4 givenname: Hiroshi surname: Kajikawa fullname: Kajikawa, Hiroshi organization: Department of Neurosurgery, Suiseikai Kajikawa Hospital, Hiroshima, Japan – sequence: 5 givenname: Shigenobu surname: Nakamura fullname: Nakamura, Shigenobu organization: Third Department of Internal Medicine, Hiroshima University School of Medicine |
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CitedBy_id | crossref_primary_10_1038_ajh_2012_85 crossref_primary_10_1016_j_jstrokecerebrovasdis_2010_11_003 crossref_primary_10_1182_bloodadvances_2019000979 crossref_primary_10_1177_1076029612452115 crossref_primary_10_1016_j_jstrokecerebrovasdis_2005_09_005 crossref_primary_10_1161_STROKEAHA_109_576223 crossref_primary_10_1186_s12987_022_00371_7 crossref_primary_10_1111_j_1468_1331_2004_00776_x |
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Keywords | white blood cell Acute ischemic stroke von Willebrand factor thrombomodulin |
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SubjectTerms | Acute ischemic stroke thrombomodulin von Willebrand factor white blood cell |
Title | Sequential changes in von Willebrand factor and soluble thrombomodulin in acute ischemic stroke |
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