Antioxidant and anti-inflammatory effects of curcumin/turmeric supplementation in adults: A GRADE-assessed systematic review and dose–response meta-analysis of randomized controlled trials

•Multiple research have focused on turmeric and its most notable bioactive component, curcumin.•Inflammatory or oxidative condition is linked to CVDs, cancer, and other diseases.•Curcumin/turmeric could improve inflammatory/oxidative markers. Turmeric and its prominent bioactive compound, curcumin,...

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Published inCytokine (Philadelphia, Pa.) Vol. 164; p. 156144
Main Authors Dehzad, Mohammad Jafar, Ghalandari, Hamid, Nouri, Mehran, Askarpour, Moein
Format Journal Article
LanguageEnglish
Published England Elsevier Ltd 01.04.2023
Subjects
Adult
Anti-Inflammatory Agents - analysis
Anti-Inflammatory Agents - pharmacology
Anti-Inflammatory Agents - therapeutic use
Antioxidant status
Antioxidants - analysis
Antioxidants - pharmacology
Antioxidants - therapeutic use
Biomarkers - analysis
C-Reactive Protein - analysis
Curcuma
Curcumin
Curcumin - pharmacology
Curcumin - therapeutic use
Dietary Supplements - analysis
Humans
Inflammation - drug therapy
Inflammation markers
Interleukin-6
Meta-analysis
Oxidative Stress - drug effects
Randomized Controlled Trials as Topic
Superoxide Dismutase
Tumor Necrosis Factor-alpha
Turmeric
Turmeric
Antioxidant status
Curcumin
Inflammation markers
Meta-analysis
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Abstract •Multiple research have focused on turmeric and its most notable bioactive component, curcumin.•Inflammatory or oxidative condition is linked to CVDs, cancer, and other diseases.•Curcumin/turmeric could improve inflammatory/oxidative markers. Turmeric and its prominent bioactive compound, curcumin, have been the subject of many investigations with regard to their impact on inflammatory and oxidative balance in the body. In this systematic review and meta-analysis, we summarized the existing literature on randomized controlled trials (RCTs) which examined this hypothesis. Major databases (PubMed, Scopus, Web of Science, Cochrane Library and Google Scholar) were searched from inception up to October 2022. Relevant studies meeting our eligibility criteria were obtained. Main outcomes included inflammatory markers (i.e. C-reactive protein(CRP), tumour necrosis factorα(TNF-α), interleukin-6(IL-6), and interleukin 1 beta(IL-1β)) and markers of oxidative stress (i.e. total antioxidant capacity (TAC), malondialdehyde(MDA), and superoxide dismutase (SOD) activity). Weighted mean differences (WMDs) were reported. P-values < 0.05 were considered significant. Sixty-six RCTs were included in the final analysis. We observed that turmeric/curcumin supplementation significantly reduces levels of inflammatory markers, including CRP (WMD: −0.58 mg/l, 95 % CI: −0.74, −0.41), TNF-α (WMD: −3.48 pg/ml, 95 % CI: −4.38, −2.58), and IL-6 (WMD: −1.31 pg/ml, 95 % CI: −1.58, −0.67); except for IL-1β (WMD: −0.46 pg/ml, 95 % CI: −1.18, 0.27) for which no significant change was found. Also, turmeric/curcumin supplementation significantly improved anti-oxidant activity through enhancing TAC (WMD = 0.21 mmol/l; 95 % CI: 0.08, 0.33), reducing MDA levels (WMD = -0.33 µmol /l; 95 % CI: −0.53, −0.12), and SOD activity (WMD = 20.51 u/l; 95 % CI: 7.35, 33.67). It seems that turmeric/curcumin supplementation might be used as a viable intervention for improving inflammatory/oxidative status of individuals.
AbstractList Turmeric and its prominent bioactive compound, curcumin, have been the subject of many investigations with regard to their impact on inflammatory and oxidative balance in the body. In this systematic review and meta-analysis, we summarized the existing literature on randomized controlled trials (RCTs) which examined this hypothesis. Major databases (PubMed, Scopus, Web of Science, Cochrane Library and Google Scholar) were searched from inception up to October 2022. Relevant studies meeting our eligibility criteria were obtained. Main outcomes included inflammatory markers (i.e. C-reactive protein(CRP), tumour necrosis factorα(TNF-α), interleukin-6(IL-6), and interleukin 1 beta(IL-1β)) and markers of oxidative stress (i.e. total antioxidant capacity (TAC), malondialdehyde(MDA), and superoxide dismutase (SOD) activity). Weighted mean differences (WMDs) were reported. P-values < 0.05 were considered significant. Sixty-six RCTs were included in the final analysis. We observed that turmeric/curcumin supplementation significantly reduces levels of inflammatory markers, including CRP (WMD: -0.58 mg/l, 95 % CI: -0.74, -0.41), TNF-α (WMD: -3.48 pg/ml, 95 % CI: -4.38, -2.58), and IL-6 (WMD: -1.31 pg/ml, 95 % CI: -1.58, -0.67); except for IL-1β (WMD: -0.46 pg/ml, 95 % CI: -1.18, 0.27) for which no significant change was found. Also, turmeric/curcumin supplementation significantly improved anti-oxidant activity through enhancing TAC (WMD = 0.21 mmol/l; 95 % CI: 0.08, 0.33), reducing MDA levels (WMD = -0.33 µmol /l; 95 % CI: -0.53, -0.12), and SOD activity (WMD = 20.51 u/l; 95 % CI: 7.35, 33.67). It seems that turmeric/curcumin supplementation might be used as a viable intervention for improving inflammatory/oxidative status of individuals.Turmeric and its prominent bioactive compound, curcumin, have been the subject of many investigations with regard to their impact on inflammatory and oxidative balance in the body. In this systematic review and meta-analysis, we summarized the existing literature on randomized controlled trials (RCTs) which examined this hypothesis. Major databases (PubMed, Scopus, Web of Science, Cochrane Library and Google Scholar) were searched from inception up to October 2022. Relevant studies meeting our eligibility criteria were obtained. Main outcomes included inflammatory markers (i.e. C-reactive protein(CRP), tumour necrosis factorα(TNF-α), interleukin-6(IL-6), and interleukin 1 beta(IL-1β)) and markers of oxidative stress (i.e. total antioxidant capacity (TAC), malondialdehyde(MDA), and superoxide dismutase (SOD) activity). Weighted mean differences (WMDs) were reported. P-values < 0.05 were considered significant. Sixty-six RCTs were included in the final analysis. We observed that turmeric/curcumin supplementation significantly reduces levels of inflammatory markers, including CRP (WMD: -0.58 mg/l, 95 % CI: -0.74, -0.41), TNF-α (WMD: -3.48 pg/ml, 95 % CI: -4.38, -2.58), and IL-6 (WMD: -1.31 pg/ml, 95 % CI: -1.58, -0.67); except for IL-1β (WMD: -0.46 pg/ml, 95 % CI: -1.18, 0.27) for which no significant change was found. Also, turmeric/curcumin supplementation significantly improved anti-oxidant activity through enhancing TAC (WMD = 0.21 mmol/l; 95 % CI: 0.08, 0.33), reducing MDA levels (WMD = -0.33 µmol /l; 95 % CI: -0.53, -0.12), and SOD activity (WMD = 20.51 u/l; 95 % CI: 7.35, 33.67). It seems that turmeric/curcumin supplementation might be used as a viable intervention for improving inflammatory/oxidative status of individuals.
•Multiple research have focused on turmeric and its most notable bioactive component, curcumin.•Inflammatory or oxidative condition is linked to CVDs, cancer, and other diseases.•Curcumin/turmeric could improve inflammatory/oxidative markers. Turmeric and its prominent bioactive compound, curcumin, have been the subject of many investigations with regard to their impact on inflammatory and oxidative balance in the body. In this systematic review and meta-analysis, we summarized the existing literature on randomized controlled trials (RCTs) which examined this hypothesis. Major databases (PubMed, Scopus, Web of Science, Cochrane Library and Google Scholar) were searched from inception up to October 2022. Relevant studies meeting our eligibility criteria were obtained. Main outcomes included inflammatory markers (i.e. C-reactive protein(CRP), tumour necrosis factorα(TNF-α), interleukin-6(IL-6), and interleukin 1 beta(IL-1β)) and markers of oxidative stress (i.e. total antioxidant capacity (TAC), malondialdehyde(MDA), and superoxide dismutase (SOD) activity). Weighted mean differences (WMDs) were reported. P-values < 0.05 were considered significant. Sixty-six RCTs were included in the final analysis. We observed that turmeric/curcumin supplementation significantly reduces levels of inflammatory markers, including CRP (WMD: −0.58 mg/l, 95 % CI: −0.74, −0.41), TNF-α (WMD: −3.48 pg/ml, 95 % CI: −4.38, −2.58), and IL-6 (WMD: −1.31 pg/ml, 95 % CI: −1.58, −0.67); except for IL-1β (WMD: −0.46 pg/ml, 95 % CI: −1.18, 0.27) for which no significant change was found. Also, turmeric/curcumin supplementation significantly improved anti-oxidant activity through enhancing TAC (WMD = 0.21 mmol/l; 95 % CI: 0.08, 0.33), reducing MDA levels (WMD = -0.33 µmol /l; 95 % CI: −0.53, −0.12), and SOD activity (WMD = 20.51 u/l; 95 % CI: 7.35, 33.67). It seems that turmeric/curcumin supplementation might be used as a viable intervention for improving inflammatory/oxidative status of individuals.
Turmeric and its prominent bioactive compound, curcumin, have been the subject of many investigations with regard to their impact on inflammatory and oxidative balance in the body. In this systematic review and meta-analysis, we summarized the existing literature on randomized controlled trials (RCTs) which examined this hypothesis. Major databases (PubMed, Scopus, Web of Science, Cochrane Library and Google Scholar) were searched from inception up to October 2022. Relevant studies meeting our eligibility criteria were obtained. Main outcomes included inflammatory markers (i.e. C-reactive protein(CRP), tumour necrosis factorα(TNF-α), interleukin-6(IL-6), and interleukin 1 beta(IL-1β)) and markers of oxidative stress (i.e. total antioxidant capacity (TAC), malondialdehyde(MDA), and superoxide dismutase (SOD) activity). Weighted mean differences (WMDs) were reported. P-values < 0.05 were considered significant. Sixty-six RCTs were included in the final analysis. We observed that turmeric/curcumin supplementation significantly reduces levels of inflammatory markers, including CRP (WMD: -0.58 mg/l, 95 % CI: -0.74, -0.41), TNF-α (WMD: -3.48 pg/ml, 95 % CI: -4.38, -2.58), and IL-6 (WMD: -1.31 pg/ml, 95 % CI: -1.58, -0.67); except for IL-1β (WMD: -0.46 pg/ml, 95 % CI: -1.18, 0.27) for which no significant change was found. Also, turmeric/curcumin supplementation significantly improved anti-oxidant activity through enhancing TAC (WMD = 0.21 mmol/l; 95 % CI: 0.08, 0.33), reducing MDA levels (WMD = -0.33 µmol /l; 95 % CI: -0.53, -0.12), and SOD activity (WMD = 20.51 u/l; 95 % CI: 7.35, 33.67). It seems that turmeric/curcumin supplementation might be used as a viable intervention for improving inflammatory/oxidative status of individuals.
ArticleNumber 156144
Author Nouri, Mehran
Askarpour, Moein
Ghalandari, Hamid
Dehzad, Mohammad Jafar
Author_xml – sequence: 1
  givenname: Mohammad Jafar
  surname: Dehzad
  fullname: Dehzad, Mohammad Jafar
  organization: Student Research Committee, Department of Clinical Nutrition, School of Nutrition and Food Sciences, Shiraz University of Medical Sciences, Shiraz, Iran
– sequence: 2
  givenname: Hamid
  surname: Ghalandari
  fullname: Ghalandari, Hamid
  organization: Student Research Committee, Department of community Nutrition, School of Nutrition and Food Sciences, Shiraz University of Medical Sciences, Shiraz, Iran
– sequence: 3
  givenname: Mehran
  surname: Nouri
  fullname: Nouri, Mehran
  organization: Student Research Committee, Department of community Nutrition, School of Nutrition and Food Sciences, Shiraz University of Medical Sciences, Shiraz, Iran
– sequence: 4
  givenname: Moein
  surname: Askarpour
  fullname: Askarpour, Moein
  email: moeinaskarpour@sums.ac.ir
  organization: Student Research Committee, Department of Clinical Nutrition, School of Nutrition and Food Sciences, Shiraz University of Medical Sciences, Shiraz, Iran
BackLink https://www.ncbi.nlm.nih.gov/pubmed/36804260$$D View this record in MEDLINE/PubMed
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Tue Jul 01 03:32:31 EDT 2025
Thu Apr 24 23:01:03 EDT 2025
Fri Feb 23 02:37:41 EST 2024
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Keywords Turmeric
Antioxidant status
Curcumin
Inflammation markers
Meta-analysis
Language English
License Copyright © 2023 Elsevier Ltd. All rights reserved.
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M. S. Campbell, A. Ouyang, K. I.M, R. J. Charnigo, P. M. Westg
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Snippet •Multiple research have focused on turmeric and its most notable bioactive component, curcumin.•Inflammatory or oxidative condition is linked to CVDs, cancer,...
Turmeric and its prominent bioactive compound, curcumin, have been the subject of many investigations with regard to their impact on inflammatory and oxidative...
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SubjectTerms Adult
Anti-Inflammatory Agents - analysis
Anti-Inflammatory Agents - pharmacology
Anti-Inflammatory Agents - therapeutic use
Antioxidant status
Antioxidants - analysis
Antioxidants - pharmacology
Antioxidants - therapeutic use
Biomarkers - analysis
C-Reactive Protein - analysis
Curcuma
Curcumin
Curcumin - pharmacology
Curcumin - therapeutic use
Dietary Supplements - analysis
Humans
Inflammation - drug therapy
Inflammation markers
Interleukin-6
Meta-analysis
Oxidative Stress - drug effects
Randomized Controlled Trials as Topic
Superoxide Dismutase
Tumor Necrosis Factor-alpha
Turmeric
Title Antioxidant and anti-inflammatory effects of curcumin/turmeric supplementation in adults: A GRADE-assessed systematic review and dose–response meta-analysis of randomized controlled trials
URI https://dx.doi.org/10.1016/j.cyto.2023.156144
https://www.ncbi.nlm.nih.gov/pubmed/36804260
https://www.proquest.com/docview/2778976038
Volume 164
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