Protective effects of curcumin against human immunodeficiency virus 1 gp120 V3 loop-induced neuronal injury in rats

Curcumin improves the learning and memory deficits in rats induced by the gp120 V3 loop. The present study cultured rat hippocampal neurons with 1 nM gp120 V3 loop and 1 μM curcumin for 24 hours. The results showed that curcumin inhibited the gp120 V3 loop-induced mitochondrial membrane potential de...

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Published in	Neural regeneration research Vol. 7; no. 3; pp. 171 - 175
Main Authors	Gong, Zheng, Yang, Lijuan, Tang, Hongmei, Pan, Rui, Xie, Sai, Guo, Luyan, Wang, Junbin, Deng, Qinyin, Xiong, Guoyin, Xing, Yanyan, Dong, Jun
Format	Journal Article
Language	English
Published	India Medknow Publications & Media Pvt. Ltd 25.01.2012 Joint Laboratory for Brain Function and Health of Jinan University and the University of Hongkong, Guangzh%Department of Orthopedics, First Affiliated Hospital, Medical College of Jinan University, Guangzhou 510632, Guangdong Province, China Institute of Brain Research, Medical College of Jinan University, Guangzhou 510632, Guangdong Province, China Department of Pathophysiology, Key Laboratory of State Administration of Traditional Chinese Medicine, Medical College of Jinan University, Guangzhou 510632, Guangdong Province, China Medknow Publications & Media Pvt Ltd
Subjects	Apoptosis caspase-3 Drug dosages Experiments Glycoproteins HIV Human immunodeficiency virus Molecular weight Morphology Nervous system Neurons Peptides Research and Report: Traditional Chinese Medicine and Neuroregeneration Studies 人类免疫缺陷病毒保护作用大鼠姜黄素海马神经元神经元损伤诱导 China gp120 V3 loop neural regeneration mitochondrial membrane potential human immunodeficiency virus-associated neurocognitive function hippocampal neurons caspase-3 curcumin
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ISSN	1673-5374 1876-7958
DOI	10.3969/j.issn.1673-5374.2012.03.002

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Abstract	Curcumin improves the learning and memory deficits in rats induced by the gp120 V3 loop. The present study cultured rat hippocampal neurons with 1 nM gp120 V3 loop and 1 μM curcumin for 24 hours. The results showed that curcumin inhibited the gp120 V3 loop-induced mitochondrial membrane potential decrease, reduced the mRNA expression of the pro-apoptotic gene caspase-3, and attenuated hippocampal neuronal injury.
AbstractList	Curcumin improves the learning and memory deficits in rats induced by the gp120 V3 loop. The present study cultured rat hippocampal neurons with 1 nM gp120 V3 loop and 1 μM curcumin for 24 hours. The results showed that curcumin inhibited the gp120 V3 loop-induced mitochondrial membrane potential decrease, reduced the mRNA expression of the pro-apoptotic gene caspase-3, and attenuated hippocampal neuronal injury. Q189; Curcumin improves the learning and memory deficits in rats induced by the gp120 V3 loop. The present study cultured rat hippocampal neurons with 1 nM gp120 V3 loop and 1 μM curcumin for 24 hours. The results showed that curcumin inhibited the gp120 V3 loop-induced mitochondrial membrane potential decrease, reduced the mRNA expression of the pro-apoptotic gene caspase-3, and attenuated hippocampal neuronal injury.
Author	Zheng Gong Lijuan Yang Hongmei Tang Rui Pan Sai Xie Luyan Guo Junbin Wang Qinyin Deng Guoyin Xiong Yanyan Xing Jun Dong
AuthorAffiliation	Department of Pathophysiology, Key Laboratory of State Administration of Traditional Chinese Medicine, Medical College of Jinan University,Guangzhou 510632, Guangdong Province, China Institute of Brain Research, Medical College of Jinan University, Guangzhou 510632, Guangdong Province, China Joint Laboratory for Brain Function and Health of Jinan University and the University of Hongkong, Guangzhou 510632, GuangdongProvince, China Department of Orthopedics, First Affiliated Hospital, Medical College of Jinan University, Guangzhou 510632, Guangdong Province, China
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Institute of Brain Research, Medical College of Jinan University, Guangzhou 510632, Guangdong Province, China ; Joint Laboratory for Brain Function and Health of Jinan University and the University of Hongkong, Guangzhou 510632, Guangdong Province, China – sequence: 7 givenname: Junbin surname: Wang fullname: Wang, Junbin organization: Department of Pathophysiology, Key Laboratory of State Administration of Traditional Chinese Medicine, Medical College of Jinan University, Guangzhou 510632, Guangdong Province, China ; Institute of Brain Research, Medical College of Jinan University, Guangzhou 510632, Guangdong Province, China ; Joint Laboratory for Brain Function and Health of Jinan University and the University of Hongkong, Guangzhou 510632, Guangdong Province, China – sequence: 8 givenname: Qinyin surname: Deng fullname: Deng, Qinyin organization: Department of Pathophysiology, Key Laboratory of State Administration of Traditional Chinese Medicine, Medical College of Jinan University, Guangzhou 510632, Guangdong Province, China ; Institute of Brain Research, Medical College of Jinan University, Guangzhou 510632, Guangdong Province, China ; Joint Laboratory for Brain Function and Health of Jinan University and the University of Hongkong, Guangzhou 510632, Guangdong Province, China – sequence: 9 givenname: Guoyin surname: Xiong fullname: Xiong, Guoyin organization: Department of Pathophysiology, Key Laboratory of State Administration of Traditional Chinese Medicine, Medical College of Jinan University, Guangzhou 510632, Guangdong Province, China ; Institute of Brain Research, Medical College of Jinan University, Guangzhou 510632, Guangdong Province, China ; Joint Laboratory for Brain Function and Health of Jinan University and the University of Hongkong, Guangzhou 510632, Guangdong Province, China – sequence: 10 givenname: Yanyan surname: Xing fullname: Xing, Yanyan organization: Department of Pathophysiology, Key Laboratory of State Administration of Traditional Chinese Medicine, Medical College of Jinan University, Guangzhou 510632, Guangdong Province, China ; Institute of Brain Research, Medical College of Jinan University, Guangzhou 510632, Guangdong Province, China ; Joint Laboratory for Brain Function and Health of Jinan University and the University of Hongkong, Guangzhou 510632, Guangdong Province, China – sequence: 11 givenname: Jun surname: Dong fullname: Dong, Jun organization: Department of Pathophysiology, Key Laboratory of State Administration of Traditional Chinese Medicine, Medical College of Jinan University, Guangzhou 510632, Guangdong Province, China ; Institute of Brain Research, Medical College of Jinan University, Guangzhou 510632, Guangdong Province, China ; Joint Laboratory for Brain Function and Health of Jinan University and the University of Hongkong, Guangzhou 510632, Guangdong Province, China
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Keywords	gp120 V3 loop neural regeneration mitochondrial membrane potential human immunodeficiency virus-associated neurocognitive function hippocampal neurons caspase-3 curcumin
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Notes	Curcumin improves the learning and memory deficits in rats induced by the gp120 V3 loop. The present study cultured rat hippocampal neurons with 1 nM gp120 V3 loop and 1 μM curcumin for 24 hours. The results showed that curcumin inhibited the gp120 V3 loop-induced mitochondrial membrane potential decrease, reduced the mRNA expression of the pro-apoptotic gene caspase-3, and attenuated hippocampal neuronal injury. curcumin; gp120 V3 loop; hippocampal neurons; mitochondrial membrane potential; caspase-3; human immunodeficiency virus-associated neurocognitive function; neural regeneration 11-5422/R ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 14 content type line 23 Author contributions: Zheng Gong, Lijuan Yang, Hongmei Tang, and Jun Dong designed the study. Zheng Gong, Lijuan Yang, Sai Xie, Luyan Guo, Junbin Wang, Qinyin Deng, and Guoyin Xiong, and Yanyan Xing conducted the experiments. Rui Pan provided analytic tools and analyzed the data. Zheng Gong, Studying for doctorate, Department of Pathophysiology, Key Laboratory of State Administration of Traditional Chinese Medicine, Medical College of Jinan University, Guangzhou 510632, Guangdong Province, China; Institute of Brain Research, Medical College of Jinan University, Guangzhou 510632, Guangdong Province, China; Joint Laboratory for Brain Function and Health of Jinan University and the University of Hongkong, Guangzhou 510632, Guangdong Province, China Zheng Gong and Lijuan Yang contributed equally to this work.
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Publisher	Medknow Publications & Media Pvt. Ltd Joint Laboratory for Brain Function and Health of Jinan University and the University of Hongkong, Guangzh%Department of Orthopedics, First Affiliated Hospital, Medical College of Jinan University, Guangzhou 510632, Guangdong Province, China Institute of Brain Research, Medical College of Jinan University, Guangzhou 510632, Guangdong Province, China Department of Pathophysiology, Key Laboratory of State Administration of Traditional Chinese Medicine, Medical College of Jinan University, Guangzhou 510632, Guangdong Province, China Medknow Publications & Media Pvt Ltd
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Snippet	Curcumin improves the learning and memory deficits in rats induced by the gp120 V3 loop. The present study cultured rat hippocampal neurons with 1 nM gp120 V3... Q189; Curcumin improves the learning and memory deficits in rats induced by the gp120 V3 loop. The present study cultured rat hippocampal neurons with 1 nM...
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SubjectTerms	Apoptosis caspase-3 Drug dosages Experiments Glycoproteins HIV Human immunodeficiency virus Molecular weight Morphology Nervous system Neurons Peptides Research and Report: Traditional Chinese Medicine and Neuroregeneration Studies 人类免疫缺陷病毒保护作用大鼠姜黄素海马神经元神经元损伤诱导
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Title	Protective effects of curcumin against human immunodeficiency virus 1 gp120 V3 loop-induced neuronal injury in rats
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