Discovery of novel pyrazolopyrimidine derivatives as potent mTOR/HDAC bi-functional inhibitors via pharmacophore-merging strategy - Zhang, Mingming; Wei, Wei; Peng, Chengjun; Ma, Xiaodong; He, Xiao; Zhang, Heng; Zhou, Mingkang (Bioorganic & medicinal chemistry letters, 2021)
Keywords: Cell Line, Tumor; Cell Proliferation - drug effects; Chemistry; Chemistry, Medicinal; Chemistry, Organic; Drug resistance; HDAC; Histone Deacetylase Inhibitors - chemical synthesis; Histone Deacetylase Inhibitors - metabolism; Histone Deacetylase Inhibitors - pharmacology; Histone Deacetylases - metabolism; Humans; Life Sciences & Biomedicine; Molecular Docking Simulation; mTOR; MTOR Inhibitors - chemical synthesis; MTOR Inhibitors - metabolism; MTOR Inhibitors - pharmacology; Pharmacology & Pharmacy; Pharmacophore-merging strategy; Physical Sciences; Polypharmacological; Protein Binding; Pyrazoles - chemical synthesis; Pyrazoles - metabolism; Pyrazoles - pharmacology; Pyrimidines - chemical synthesis; Pyrimidines - metabolism; Pyrimidines - pharmacology; Science & Technology; TOR Serine-Threonine Kinases - antagonists & inhibitors; TOR Serine-Threonine Kinases - metabolism; mTOR; Drug resistance; Pharmacophore-merging strategy; Polypharmacological; HDAC; TARGET; HISTONE DEACETYLASE INHIBITOR; IN-VITRO; POLYPHARMACOLOGY; DESIGN; ANTITUMOR-ACTIVITY; PHASE-I