Gankyrin promotes epithelial-mesenchymal transition and metastasis in NSCLC through forming a closed circle with IL-6/ STAT3 and TGF-β/SMAD3 signaling pathway

• Published in: Oncotarget Vol. 8; no. 4; pp. 5909 - 5923
• Main Authors: Wang, Wu-Ping, Sun, Ying, Lu, Qiang, Zhao, Jin-Bo, Wang, Xue-Jiao, Chen, Zhao, Ni, Yun-Feng, Wang, Ju-Zheng, Han, Yong, Zhang, Zhi-Pei, Yan, Xiao-Long, Li, Xiao-Fei
• Format: Journal Article
• Language: English
• Published: United States Impact Journals LLC 24.01.2017
• Subjects: A549 Cells; Carcinoma, Non-Small-Cell Lung - genetics; Carcinoma, Non-Small-Cell Lung - metabolism; Cell Line, Tumor; Epithelial-Mesenchymal Transition; Gene Expression Regulation, Neoplastic; Humans; Interleukin-6 - genetics; Interleukin-6 - metabolism; Lung Neoplasms - genetics; Lung Neoplasms - metabolism; Neoplasm Metastasis; Proteasome Endopeptidase Complex - genetics; Proteasome Endopeptidase Complex - metabolism; Proto-Oncogene Proteins - genetics; Proto-Oncogene Proteins - metabolism; Research Paper; Signal Transduction; Smad3 Protein - genetics; Smad3 Protein - metabolism; STAT3 Transcription Factor - genetics; STAT3 Transcription Factor - metabolism; Transforming Growth Factor beta - genetics; Transforming Growth Factor beta - metabolism; Up-Regulation; gankyrin; closed circle; NSCLC; metastasis; EMT

Our previous research showed that Gankyrin was overexpressed in NSCLC and significantly associated with clinicopathologic features and poor prognosis. In this study, we will explore potential effect of Gankyrin on EMT and metastasis in NSCLC. The ectopic higher expression of Gankyrin markedly increa...