Modulation of monocytes by bioactive lipid anandamide in multiple sclerosis involves distinct Toll-like receptors

• Published in: Pharmacological research Vol. 113; no. Pt A; pp. 313 - 319
• Main Authors: Chiurchiù, Valerio, Leuti, Alessandro, Cencioni, Maria Teresa, Albanese, Maria, De Bardi, Marco, Bisogno, Tiziana, Centonze, Diego, Battistini, Luca, Maccarrone, Mauro
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier Ltd 01.11.2016
• Subjects: Adult; Arachidonic Acids - therapeutic use; Bioactive lipids; Endocannabinoids; Endocannabinoids - metabolism; Endocannabinoids - therapeutic use; Female; Humans; Immunologic Factors - therapeutic use; Immunomodulation; Immunosuppressive Agents - therapeutic use; Interleukin-12 - metabolism; Interleukin-6 - metabolism; Lipids - therapeutic use; Male; Monocytes - drug effects; Monocytes - metabolism; Multiple sclerosis; Multiple Sclerosis - drug therapy; Multiple Sclerosis - metabolism; Polyunsaturated Alkamides - therapeutic use; Signal Transduction - drug effects; Toll-Like Receptor 2 - metabolism; Toll-Like Receptor 4 - metabolism; Toll-like receptors; Tumor Necrosis Factor-alpha - metabolism; Toll-like receptors; Multiple sclerosis; Bioactive lipids; Immunomodulation; Endocannabinoids

[Display omitted] Monocytes are believed to be involved in the immunopathogenesis of multiple sclerosis (MS). The aim of this study was to investigate their role in MS and their immunomodulation by the endocannabinoid system (ECS), a novel target for the treatment of this disease. We compared the le...