Alleviation of neurotoxicity induced by polystyrene nanoplastics by increased exocytosis from neurons
Nanoplastics (NPs) are potentially toxic and pose a health risk as they can induce an inflammatory response and oxidative stress at cellular and organismal levels. Humans can be exposed to NPs through various routes, including ingestion, inhalation, and skin contact. Notably, uptake into the body vi...
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Published in | Biochemical and biophysical research communications Vol. 668; pp. 19 - 26 |
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Format | Journal Article |
Language | English |
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Elsevier Inc
06.08.2023
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Abstract | Nanoplastics (NPs) are potentially toxic and pose a health risk as they can induce an inflammatory response and oxidative stress at cellular and organismal levels. Humans can be exposed to NPs through various routes, including ingestion, inhalation, and skin contact. Notably, uptake into the body via inhalation could result in brain accumulation, which may occur directly across the blood-brain barrier or via other routes. NPs that accumulate in the brain may be endocytosed into neurons, inducing neurotoxicity. Recently, we demonstrated that exposure to polystyrene (PS)-NPs reduces the viability of neurons. We have also reported that inhibiting the retrograde transport of PS-NPs by histone deacetylase 6 (HDAC6) prevents their intracellular accumulation and promotes their export in mouse embryonic fibroblasts. However, whether HDAC6 inhibition can improve neuronal viability by increasing exocytosis of PS-NPs from neurons remains unknown. In this study, mice were intranasally administered fluorescent PS-NPs (PS-YG), which accumulated in the brain and showed potential neurotoxic effects. In cultured neurons, the HDAC6 inhibitor ACY-1215 reduced the fluorescence signal detected from PS-YG, suggesting that the removal of PS-YG from neurons was promoted. Therefore, these results suggest that blocking the retrograde transport of PS-NPs using an HDAC6 inhibitor can alleviate the neurotoxic effects of PS-NPs that enter the brain.
•Intranasal administration of PS-NPs causes their accumulation in the mouse brain.•PS-NP accumulation in the mouse brain induces acute neurotoxic effects.•HDAC6 inhibition results in the rapid export of PS-NPs from neurons by exocytosis.•The rapid export of PS-NPs from neurons alleviates neurotoxic effects of PS-NPs.•The rapid export of PS-NPs from neurons reduces oxidative stress induced by PS-NPs. |
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AbstractList | Nanoplastics (NPs) are potentially toxic and pose a health risk as they can induce an inflammatory response and oxidative stress at cellular and organismal levels. Humans can be exposed to NPs through various routes, including ingestion, inhalation, and skin contact. Notably, uptake into the body via inhalation could result in brain accumulation, which may occur directly across the blood-brain barrier or via other routes. NPs that accumulate in the brain may be endocytosed into neurons, inducing neurotoxicity. Recently, we demonstrated that exposure to polystyrene (PS)-NPs reduces the viability of neurons. We have also reported that inhibiting the retrograde transport of PS-NPs by histone deacetylase 6 (HDAC6) prevents their intracellular accumulation and promotes their export in mouse embryonic fibroblasts. However, whether HDAC6 inhibition can improve neuronal viability by increasing exocytosis of PS-NPs from neurons remains unknown. In this study, mice were intranasally administered fluorescent PS-NPs (PS-YG), which accumulated in the brain and showed potential neurotoxic effects. In cultured neurons, the HDAC6 inhibitor ACY-1215 reduced the fluorescence signal detected from PS-YG, suggesting that the removal of PS-YG from neurons was promoted. Therefore, these results suggest that blocking the retrograde transport of PS-NPs using an HDAC6 inhibitor can alleviate the neurotoxic effects of PS-NPs that enter the brain. Nanoplastics (NPs) are potentially toxic and pose a health risk as they can induce an inflammatory response and oxidative stress at cellular and organismal levels. Humans can be exposed to NPs through various routes, including ingestion, inhalation, and skin contact. Notably, uptake into the body via inhalation could result in brain accumulation, which may occur directly across the blood-brain barrier or via other routes. NPs that accumulate in the brain may be endocytosed into neurons, inducing neurotoxicity. Recently, we demonstrated that exposure to polystyrene (PS)-NPs reduces the viability of neurons. We have also reported that inhibiting the retrograde transport of PS-NPs by histone deacetylase 6 (HDAC6) prevents their intracellular accumulation and promotes their export in mouse embryonic fibroblasts. However, whether HDAC6 inhibition can improve neuronal viability by increasing exocytosis of PS-NPs from neurons remains unknown. In this study, mice were intranasally administered fluorescent PS-NPs (PS-YG), which accumulated in the brain and showed potential neurotoxic effects. In cultured neurons, the HDAC6 inhibitor ACY-1215 reduced the fluorescence signal detected from PS-YG, suggesting that the removal of PS-YG from neurons was promoted. Therefore, these results suggest that blocking the retrograde transport of PS-NPs using an HDAC6 inhibitor can alleviate the neurotoxic effects of PS-NPs that enter the brain. •Intranasal administration of PS-NPs causes their accumulation in the mouse brain.•PS-NP accumulation in the mouse brain induces acute neurotoxic effects.•HDAC6 inhibition results in the rapid export of PS-NPs from neurons by exocytosis.•The rapid export of PS-NPs from neurons alleviates neurotoxic effects of PS-NPs.•The rapid export of PS-NPs from neurons reduces oxidative stress induced by PS-NPs. |
Author | Choi, Jinhee Bae, Jin-Sil Han, Seung-Woo Kim, Taek-Yeong Ryu, Kwon-Yul |
Author_xml | – sequence: 1 givenname: Seung-Woo surname: Han fullname: Han, Seung-Woo organization: Department of Life Science, University of Seoul, Seoul, 02504, South Korea – sequence: 2 givenname: Taek-Yeong surname: Kim fullname: Kim, Taek-Yeong organization: Department of Life Science, University of Seoul, Seoul, 02504, South Korea – sequence: 3 givenname: Jin-Sil surname: Bae fullname: Bae, Jin-Sil organization: Department of Life Science, University of Seoul, Seoul, 02504, South Korea – sequence: 4 givenname: Jinhee orcidid: 0000-0003-3393-7505 surname: Choi fullname: Choi, Jinhee organization: School of Environmental Engineering, University of Seoul, Seoul, 02504, South Korea – sequence: 5 givenname: Kwon-Yul orcidid: 0000-0001-6104-8575 surname: Ryu fullname: Ryu, Kwon-Yul email: kyryu@uos.ac.kr organization: Department of Life Science, University of Seoul, Seoul, 02504, South Korea |
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Cites_doi | 10.1016/j.marpolbul.2018.05.047 10.1016/j.scitotenv.2019.134455 10.1021/acs.nanolett.1c04184 10.1039/C8NR09321K 10.1074/jbc.M300227200 10.1038/emboj.2009.405 10.1016/j.watres.2019.02.054 10.1098/rstb.2008.0205 10.1096/fj.11-202457 10.1016/j.jhazmat.2019.121788 10.1038/srep07026 10.1016/j.chemosphere.2020.128330 10.3390/ijms22042094 10.1016/j.neuro.2020.10.008 10.1152/ajplung.00283.2002 10.1016/j.jhazmat.2021.127815 10.1016/j.jhazmat.2022.129576 10.1016/j.envpol.2017.11.043 10.1038/ng1591 10.1016/j.marpolbul.2022.113832 10.1073/pnas.1218497110 10.1016/j.envpol.2014.01.019 10.1016/j.scitotenv.2020.142518 10.1247/csf.08005 |
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Keywords | NPs Oxidative stress PS Inflammation Exocytosis Retrograde transport HDAC6 Nanoplastics |
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References | Kwon, Saido, Koizumi, Sato, Ogawa, Chung, Kusui, Kodera, Kogure (bib8) 2014; 188 Barboza, Dick Vethaak, Lavorante, Lundebye, Guilhermino (bib2) 2018; 133 Barnes, Galgani, Thompson, Barlaz (bib1) 2009; 364 Bi, Huang, Tong, Qiu, Huang, Wu, Li, Xu, Bowser, Xia, Zhou (bib23) 2013; 110 Lee, Koga, Kawaguchi, Tang, Wong, Gao, Pandey, Kaushik, Tresse, Lu, Taylor, Cuervo, Yao (bib24) 2010; 29 Pauly, Stegmeier, Allaart, Cheney, Zhang, Mayer, Streck (bib10) 1998; 7 Jeong, Baek, Koo, Park, Ryu, Kim, Zhang, Chung, Dogan, Choi, Um, Kim, Lee, Jeong, Shin, Lee, Kim, Lee (bib16) 2022; 426 Sangkham, Faikhaw, Munkong, Sakunkoo, Arunlertaree, Chavali, Mousazadeh, Tiwari (bib13) 2022; 181 Prata (bib9) 2018; 234 Webb, Ravikumar, Atkins, Skepper, Rubinsztein (bib25) 2003; 278 Banerjee, Shelver (bib6) 2021; 755 Maul, Frushour, Kontoff, Eichenauer, Ott, Schade (bib7) 2007; 29 Prata, da Costa, Lopes, Duarte, Rocha-Santos (bib4) 2020; 702 Jones, Watts, Debelak, Thornton, Younger, Kline (bib12) 2003; 284 Jung, Han, Park, Bae, Choi, Ryu (bib17) 2020; 81 Hanson, Fine, Svitak, Faltesek (bib21) 2013 Liu, Zhao, Dou, Hou, Cheng, Jiang (bib14) 2022; 22 Koelmans, Mohamed Nor, Hermsen, Kooi, Mintenig, De France (bib3) 2019; 155 Lee, Cho, Kim, Huh, Kim, Kim, Kang, Lee, Jeong (bib15) 2019; 11 Lim, Jeong, Song, Sung, Oh, Choi (bib11) 2021; 262 Han, Choi, Ryu (bib18) 2021; 22 Kimura, Noda, Yoshimori (bib27) 2008; 33 Sendra, Saco, Yeste, Romero, Novoa, Figueras (bib5) 2020; 388 Ravikumar, Acevedo-Arozena, Imarisio, Berger, Vacher, O'Kane, Brown, Rubinsztein (bib26) 2005; 37 Ryu, Park, Ryu (bib20) 2014; 4 Naude, Nyakas, Eiden, Ait-Ali, van der Heide, Engelborghs, Luiten, De Deyn, den Boer, Eisel (bib22) 2012; 26 Han, Ryu (bib19) 2022; 439 Banerjee (10.1016/j.bbrc.2023.05.070_bib6) 2021; 755 Lim (10.1016/j.bbrc.2023.05.070_bib11) 2021; 262 Bi (10.1016/j.bbrc.2023.05.070_bib23) 2013; 110 Lee (10.1016/j.bbrc.2023.05.070_bib15) 2019; 11 Sangkham (10.1016/j.bbrc.2023.05.070_bib13) 2022; 181 Koelmans (10.1016/j.bbrc.2023.05.070_bib3) 2019; 155 Hanson (10.1016/j.bbrc.2023.05.070_bib21) 2013 Pauly (10.1016/j.bbrc.2023.05.070_bib10) 1998; 7 Jung (10.1016/j.bbrc.2023.05.070_bib17) 2020; 81 Barnes (10.1016/j.bbrc.2023.05.070_bib1) 2009; 364 Lee (10.1016/j.bbrc.2023.05.070_bib24) 2010; 29 Barboza (10.1016/j.bbrc.2023.05.070_bib2) 2018; 133 Prata (10.1016/j.bbrc.2023.05.070_bib9) 2018; 234 Jeong (10.1016/j.bbrc.2023.05.070_bib16) 2022; 426 Kimura (10.1016/j.bbrc.2023.05.070_bib27) 2008; 33 Maul (10.1016/j.bbrc.2023.05.070_bib7) 2007; 29 Prata (10.1016/j.bbrc.2023.05.070_bib4) 2020; 702 Naude (10.1016/j.bbrc.2023.05.070_bib22) 2012; 26 Han (10.1016/j.bbrc.2023.05.070_bib19) 2022; 439 Kwon (10.1016/j.bbrc.2023.05.070_bib8) 2014; 188 Han (10.1016/j.bbrc.2023.05.070_bib18) 2021; 22 Webb (10.1016/j.bbrc.2023.05.070_bib25) 2003; 278 Liu (10.1016/j.bbrc.2023.05.070_bib14) 2022; 22 Sendra (10.1016/j.bbrc.2023.05.070_bib5) 2020; 388 Ryu (10.1016/j.bbrc.2023.05.070_bib20) 2014; 4 Ravikumar (10.1016/j.bbrc.2023.05.070_bib26) 2005; 37 Jones (10.1016/j.bbrc.2023.05.070_bib12) 2003; 284 |
References_xml | – volume: 4 start-page: 7026 year: 2014 ident: bib20 article-title: Disruption of polyubiquitin gene Ubb causes dysregulation of neural stem cell differentiation with premature gliogenesis publication-title: Sci. Rep. contributor: fullname: Ryu – volume: 364 start-page: 1985 year: 2009 end-page: 1998 ident: bib1 article-title: Accumulation and fragmentation of plastic debris in global environments publication-title: Philos. Trans. R. Soc. Lond. B Biol. Sci. contributor: fullname: Barlaz – volume: 388 year: 2020 ident: bib5 article-title: Nanoplastics: from tissue accumulation to cell translocation into Mytilus galloprovincialis hemocytes. resilience of immune cells exposed to nanoplastics and nanoplastics plus Vibrio splendidus combination publication-title: J. Hazard Mater. contributor: fullname: Figueras – volume: 7 start-page: 419 year: 1998 end-page: 428 ident: bib10 article-title: Inhaled cellulosic and plastic fibers found in human lung tissue publication-title: Cancer Epidemiol. Biomarkers Prev. contributor: fullname: Streck – volume: 29 start-page: 969 year: 2010 end-page: 980 ident: bib24 article-title: HDAC6 controls autophagosome maturation essential for ubiquitin-selective quality-control autophagy publication-title: EMBO J. contributor: fullname: Yao – volume: 22 start-page: 2094 year: 2021 ident: bib18 article-title: Stress response of mouse embryonic fibroblasts exposed to polystyrene nanoplastics publication-title: Int. J. Mol. Sci. contributor: fullname: Ryu – volume: 439 year: 2022 ident: bib19 article-title: Increased clearance of non-biodegradable polystyrene nanoplastics by exocytosis through inhibition of retrograde intracellular transport publication-title: J. Hazard Mater. contributor: fullname: Ryu – volume: 278 start-page: 25009 year: 2003 end-page: 25013 ident: bib25 article-title: Alpha-Synuclein is degraded by both autophagy and the proteasome publication-title: J. Biol. Chem. contributor: fullname: Rubinsztein – volume: 33 start-page: 109 year: 2008 end-page: 122 ident: bib27 article-title: Dynein-dependent movement of autophagosomes mediates efficient encounters with lysosomes publication-title: Cell Struct. Funct. contributor: fullname: Yoshimori – volume: 37 start-page: 771 year: 2005 end-page: 776 ident: bib26 article-title: Dynein mutations impair autophagic clearance of aggregate-prone proteins publication-title: Nat. Genet. contributor: fullname: Rubinsztein – volume: 284 start-page: L1072 year: 2003 end-page: L1081 ident: bib12 article-title: Inhibition of prostaglandin synthesis during polystyrene microsphere-induced pulmonary embolism in the rat publication-title: Am. J. Physiol. Lung Cell Mol. Physiol. contributor: fullname: Kline – volume: 22 start-page: 1091 year: 2022 end-page: 1099 ident: bib14 article-title: Bioeffects of inhaled nanoplastics on neurons and alteration of animal behaviors through deposition in the brain publication-title: Nano Lett. contributor: fullname: Jiang – volume: 155 start-page: 410 year: 2019 end-page: 422 ident: bib3 article-title: Microplastics in freshwaters and drinking water: critical review and assessment of data quality publication-title: Water Res. contributor: fullname: De France – volume: 702 year: 2020 ident: bib4 article-title: Environmental exposure to microplastics: an overview on possible human health effects publication-title: Sci. Total Environ. contributor: fullname: Rocha-Santos – volume: 234 start-page: 115 year: 2018 end-page: 126 ident: bib9 article-title: Airborne microplastics: consequences to human health? publication-title: Environ. Pollut. contributor: fullname: Prata – volume: 262 year: 2021 ident: bib11 article-title: Inhalation toxicity of polystyrene micro(nano)plastics using modified OECD TG 412 publication-title: Chemosphere contributor: fullname: Choi – volume: 181 year: 2022 ident: bib13 article-title: A review on microplastics and nanoplastics in the environment: their occurrence, exposure routes, toxic studies, and potential effects on human health publication-title: Mar. Pollut. Bull. contributor: fullname: Tiwari – volume: 81 start-page: 189 year: 2020 end-page: 196 ident: bib17 article-title: Neurotoxic potential of polystyrene nanoplastics in primary cells originating from mouse brain publication-title: Neurotoxicology contributor: fullname: Ryu – volume: 755 year: 2021 ident: bib6 article-title: Micro- and nanoplastic induced cellular toxicity in mammals: a review publication-title: Sci. Total Environ. contributor: fullname: Shelver – volume: 133 start-page: 336 year: 2018 end-page: 348 ident: bib2 article-title: Marine microplastic debris: an emerging issue for food security, food safety and human health publication-title: Mar. Pollut. Bull. contributor: fullname: Guilhermino – volume: 188 start-page: 45 year: 2014 end-page: 49 ident: bib8 article-title: Regional distribution of styrene analogues generated from polystyrene degradation along the coastlines of the North-East Pacific Ocean and Hawaii publication-title: Environ. Pollut. contributor: fullname: Kogure – volume: 26 start-page: 2811 year: 2012 end-page: 2823 ident: bib22 article-title: Lipocalin 2: novel component of proinflammatory signaling in Alzheimer’s disease publication-title: FASEB. J. contributor: fullname: Eisel – volume: 426 year: 2022 ident: bib16 article-title: Maternal exposure to polystyrene nanoplastics causes brain abnormalities in progeny publication-title: J. Hazard Mater. contributor: fullname: Lee – start-page: 4440 year: 2013 ident: bib21 article-title: Intranasal administration of CNS therapeutics to awake mice publication-title: J. Vis. Exp. contributor: fullname: Faltesek – volume: 11 start-page: 3173 year: 2019 end-page: 3185 ident: bib15 article-title: Bioaccumulation of polystyrene nanoplastics and their effect on the toxicity of Au ions in zebrafish embryos publication-title: Nanoscale contributor: fullname: Jeong – volume: 110 start-page: 4069 year: 2013 end-page: 4074 ident: bib23 article-title: Reactive astrocytes secrete lcn2 to promote neuron death publication-title: Proc. Natl. Acad. Sci. U. S. A. contributor: fullname: Zhou – volume: 29 start-page: 475 year: 2007 end-page: 522 ident: bib7 article-title: Polystyrene and styrene copolymers publication-title: Ullmann’s Encycl. Ind. Chem. contributor: fullname: Schade – volume: 133 start-page: 336 year: 2018 ident: 10.1016/j.bbrc.2023.05.070_bib2 article-title: Marine microplastic debris: an emerging issue for food security, food safety and human health publication-title: Mar. Pollut. Bull. doi: 10.1016/j.marpolbul.2018.05.047 contributor: fullname: Barboza – volume: 702 year: 2020 ident: 10.1016/j.bbrc.2023.05.070_bib4 article-title: Environmental exposure to microplastics: an overview on possible human health effects publication-title: Sci. Total Environ. doi: 10.1016/j.scitotenv.2019.134455 contributor: fullname: Prata – volume: 22 start-page: 1091 year: 2022 ident: 10.1016/j.bbrc.2023.05.070_bib14 article-title: Bioeffects of inhaled nanoplastics on neurons and alteration of animal behaviors through deposition in the brain publication-title: Nano Lett. doi: 10.1021/acs.nanolett.1c04184 contributor: fullname: Liu – volume: 11 start-page: 3173 year: 2019 ident: 10.1016/j.bbrc.2023.05.070_bib15 article-title: Bioaccumulation of polystyrene nanoplastics and their effect on the toxicity of Au ions in zebrafish embryos publication-title: Nanoscale doi: 10.1039/C8NR09321K contributor: fullname: Lee – volume: 7 start-page: 419 year: 1998 ident: 10.1016/j.bbrc.2023.05.070_bib10 article-title: Inhaled cellulosic and plastic fibers found in human lung tissue publication-title: Cancer Epidemiol. Biomarkers Prev. contributor: fullname: Pauly – volume: 278 start-page: 25009 year: 2003 ident: 10.1016/j.bbrc.2023.05.070_bib25 article-title: Alpha-Synuclein is degraded by both autophagy and the proteasome publication-title: J. Biol. Chem. doi: 10.1074/jbc.M300227200 contributor: fullname: Webb – volume: 29 start-page: 969 year: 2010 ident: 10.1016/j.bbrc.2023.05.070_bib24 article-title: HDAC6 controls autophagosome maturation essential for ubiquitin-selective quality-control autophagy publication-title: EMBO J. doi: 10.1038/emboj.2009.405 contributor: fullname: Lee – volume: 155 start-page: 410 year: 2019 ident: 10.1016/j.bbrc.2023.05.070_bib3 article-title: Microplastics in freshwaters and drinking water: critical review and assessment of data quality publication-title: Water Res. doi: 10.1016/j.watres.2019.02.054 contributor: fullname: Koelmans – volume: 364 start-page: 1985 year: 2009 ident: 10.1016/j.bbrc.2023.05.070_bib1 article-title: Accumulation and fragmentation of plastic debris in global environments publication-title: Philos. Trans. R. Soc. Lond. B Biol. Sci. doi: 10.1098/rstb.2008.0205 contributor: fullname: Barnes – volume: 29 start-page: 475 year: 2007 ident: 10.1016/j.bbrc.2023.05.070_bib7 article-title: Polystyrene and styrene copolymers publication-title: Ullmann’s Encycl. Ind. Chem. contributor: fullname: Maul – volume: 26 start-page: 2811 year: 2012 ident: 10.1016/j.bbrc.2023.05.070_bib22 article-title: Lipocalin 2: novel component of proinflammatory signaling in Alzheimer’s disease publication-title: FASEB. J. doi: 10.1096/fj.11-202457 contributor: fullname: Naude – volume: 388 year: 2020 ident: 10.1016/j.bbrc.2023.05.070_bib5 article-title: Nanoplastics: from tissue accumulation to cell translocation into Mytilus galloprovincialis hemocytes. resilience of immune cells exposed to nanoplastics and nanoplastics plus Vibrio splendidus combination publication-title: J. Hazard Mater. doi: 10.1016/j.jhazmat.2019.121788 contributor: fullname: Sendra – start-page: 4440 year: 2013 ident: 10.1016/j.bbrc.2023.05.070_bib21 article-title: Intranasal administration of CNS therapeutics to awake mice publication-title: J. Vis. Exp. contributor: fullname: Hanson – volume: 4 start-page: 7026 year: 2014 ident: 10.1016/j.bbrc.2023.05.070_bib20 article-title: Disruption of polyubiquitin gene Ubb causes dysregulation of neural stem cell differentiation with premature gliogenesis publication-title: Sci. Rep. doi: 10.1038/srep07026 contributor: fullname: Ryu – volume: 262 year: 2021 ident: 10.1016/j.bbrc.2023.05.070_bib11 article-title: Inhalation toxicity of polystyrene micro(nano)plastics using modified OECD TG 412 publication-title: Chemosphere doi: 10.1016/j.chemosphere.2020.128330 contributor: fullname: Lim – volume: 22 start-page: 2094 year: 2021 ident: 10.1016/j.bbrc.2023.05.070_bib18 article-title: Stress response of mouse embryonic fibroblasts exposed to polystyrene nanoplastics publication-title: Int. J. Mol. Sci. doi: 10.3390/ijms22042094 contributor: fullname: Han – volume: 81 start-page: 189 year: 2020 ident: 10.1016/j.bbrc.2023.05.070_bib17 article-title: Neurotoxic potential of polystyrene nanoplastics in primary cells originating from mouse brain publication-title: Neurotoxicology doi: 10.1016/j.neuro.2020.10.008 contributor: fullname: Jung – volume: 284 start-page: L1072 year: 2003 ident: 10.1016/j.bbrc.2023.05.070_bib12 article-title: Inhibition of prostaglandin synthesis during polystyrene microsphere-induced pulmonary embolism in the rat publication-title: Am. J. Physiol. Lung Cell Mol. Physiol. doi: 10.1152/ajplung.00283.2002 contributor: fullname: Jones – volume: 426 year: 2022 ident: 10.1016/j.bbrc.2023.05.070_bib16 article-title: Maternal exposure to polystyrene nanoplastics causes brain abnormalities in progeny publication-title: J. Hazard Mater. doi: 10.1016/j.jhazmat.2021.127815 contributor: fullname: Jeong – volume: 439 year: 2022 ident: 10.1016/j.bbrc.2023.05.070_bib19 article-title: Increased clearance of non-biodegradable polystyrene nanoplastics by exocytosis through inhibition of retrograde intracellular transport publication-title: J. Hazard Mater. doi: 10.1016/j.jhazmat.2022.129576 contributor: fullname: Han – volume: 234 start-page: 115 year: 2018 ident: 10.1016/j.bbrc.2023.05.070_bib9 article-title: Airborne microplastics: consequences to human health? publication-title: Environ. Pollut. doi: 10.1016/j.envpol.2017.11.043 contributor: fullname: Prata – volume: 37 start-page: 771 year: 2005 ident: 10.1016/j.bbrc.2023.05.070_bib26 article-title: Dynein mutations impair autophagic clearance of aggregate-prone proteins publication-title: Nat. Genet. doi: 10.1038/ng1591 contributor: fullname: Ravikumar – volume: 181 year: 2022 ident: 10.1016/j.bbrc.2023.05.070_bib13 article-title: A review on microplastics and nanoplastics in the environment: their occurrence, exposure routes, toxic studies, and potential effects on human health publication-title: Mar. Pollut. Bull. doi: 10.1016/j.marpolbul.2022.113832 contributor: fullname: Sangkham – volume: 110 start-page: 4069 year: 2013 ident: 10.1016/j.bbrc.2023.05.070_bib23 article-title: Reactive astrocytes secrete lcn2 to promote neuron death publication-title: Proc. Natl. Acad. Sci. U. S. A. doi: 10.1073/pnas.1218497110 contributor: fullname: Bi – volume: 188 start-page: 45 year: 2014 ident: 10.1016/j.bbrc.2023.05.070_bib8 article-title: Regional distribution of styrene analogues generated from polystyrene degradation along the coastlines of the North-East Pacific Ocean and Hawaii publication-title: Environ. Pollut. doi: 10.1016/j.envpol.2014.01.019 contributor: fullname: Kwon – volume: 755 year: 2021 ident: 10.1016/j.bbrc.2023.05.070_bib6 article-title: Micro- and nanoplastic induced cellular toxicity in mammals: a review publication-title: Sci. Total Environ. doi: 10.1016/j.scitotenv.2020.142518 contributor: fullname: Banerjee – volume: 33 start-page: 109 year: 2008 ident: 10.1016/j.bbrc.2023.05.070_bib27 article-title: Dynein-dependent movement of autophagosomes mediates efficient encounters with lysosomes publication-title: Cell Struct. Funct. doi: 10.1247/csf.08005 contributor: fullname: Kimura |
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Snippet | Nanoplastics (NPs) are potentially toxic and pose a health risk as they can induce an inflammatory response and oxidative stress at cellular and organismal... |
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SubjectTerms | Animals Exocytosis Fibroblasts Humans Inflammation Mice Microplastics Nanoparticles - toxicity Nanoplastics Neurons Oxidative stress Polystyrenes - toxicity Retrograde transport Water Pollutants, Chemical |
Title | Alleviation of neurotoxicity induced by polystyrene nanoplastics by increased exocytosis from neurons |
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