Coronary artery disease in a child with homozygous familial hypercholesterolemia: Regression after liver transplantation

Children with homozygous familial hypercholesterolemia are at risk for early cardiovascular events secondary to coronary artery disease. Current medical therapy does not ameliorate this risk. Liver transplantation offers the most effective option to reduce circulating levels of low-density lipoprote...

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Bibliographic Details
Published inJournal of clinical lipidology Vol. 13; no. 6; pp. 880 - 886
Main Authors Cephus, Constance E., Qureshi, Athar M., Sexson Tejtel, S. Kristen, Alam, Mahboob, Moodie, Douglas S.
Format Journal Article
LanguageEnglish
Published United States Elsevier Inc 01.11.2019
Subjects
Angiogram
Cardiac catheterization
Coronary atherosclerosis
Genetic
LDL receptor
Liver transplantation
Pediatric
Regression
Treatment
Cardiac catheterization
Treatment
Coronary atherosclerosis
Regression
Genetic
Angiogram
Pediatric
Liver transplantation
LDL receptor
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Summary:Children with homozygous familial hypercholesterolemia are at risk for early cardiovascular events secondary to coronary artery disease. Current medical therapy does not ameliorate this risk. Liver transplantation offers the most effective option to reduce circulating levels of low-density lipoprotein cholesterol and thereby reduce risk of cardiovascular events. Angiographic evidence of regression of coronary artery disease is presented. •Current therapy for homozygous FH does not result in persistently normal LDL-c levels.•Contrast cCTA may provide a reliable assessment of atherosclerosis.•Study of QOL during apheresis and after liver transplantation in children is needed.•Coronary artery atherosclerosis may regress after liver transplantation.
Bibliography:ObjectType-Case Study-2
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ISSN:1933-2874
1876-4789
DOI:10.1016/j.jacl.2019.09.007