“Gold nanoparticles composite-folic acid conjugated graphene oxide nanohybrids” for targeted chemo-thermal cancer ablation: In vitro screening and in vivo studies

• Published in: European journal of pharmaceutical sciences Vol. 96; pp. 351 - 361
• Main Authors: Chauhan, Gaurav, Chopra, Vianni, Tyagi, Amit, Rath, Goutam, Sharma, Rakesh K, Goyal, Amit K.
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier B.V 01.01.2017
• Subjects: Animals; Antineoplastic Agents - administration & dosage; Cell Line, Tumor; Cell Survival - drug effects; Cell Survival - physiology; Drug Delivery Systems - methods; Drug Screening Assays, Antitumor - methods; Female; Folic Acid - administration & dosage; Gold - administration & dosage; Gold nanoparticles, targeted chemotherapy; Graphene oxide; Graphite - administration & dosage; HeLa Cells; Hot Temperature - therapeutic use; Humans; Male; MCF-7 Cells; Metal Nanoparticles - administration & dosage; Mice; Mice, Inbred BALB C; Near-infrared (NIR) sensitivity; Oxides - administration & dosage; Photo-thermal tumor ablation; Tumor Burden - drug effects; Tumor Burden - physiology; Graphene oxide; Near-infrared (NIR) sensitivity; Photo-thermal tumor ablation; Gold nanoparticles, targeted chemotherapy

Nano-graphene oxide (GO) nanometal composite (specifically nanogold and nanosilver) have shown to be a promising material for anticancer therapeutics. Owing to their high drug loading capacity, photothermal and synergizing effects, it is very important to exploit them for targeted chemo-thermal canc...