Selective degradation of BET proteins with dBET1, a proteolysis-targeting chimera, potently reduces pro-inflammatory responses in lipopolysaccharide-activated microglia

• Published in: Biochemical and biophysical research communications Vol. 497; no. 1; pp. 410 - 415
• Main Authors: DeMars, Kelly M., Yang, Changjun, Castro-Rivera, Carolina I., Candelario-Jalil, Eduardo
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 26.02.2018
• Subjects: BET proteins; dBET1; Inflammation; Lipopolysaccharide; Microglia; BET proteins; TNFα; Pol II; dBET1; TBS; COX-2; DMSO; TBST; Inflammation; IL-1β; LPS; Microglia; BET; MMP; NF-κB; PTEFb; BRD; shRNA; Lipopolysaccharide; iNOS; CCL2; TLR

Bromodomain and extraterminal (BET) proteins are essential to pro-inflammatory gene transcription. The BET family proteins, BRD2, BRD3, BRD4, and testis-specific BRDT, couple chromatin remodeling to gene transcription, acting as histone acetyltransferases, scaffolds for transcription complexes, and...