Fragmentomics profiling and quantification of plasma Epstein-Barr virus DNA enhance prediction of future nasopharyngeal carcinoma

• Published in: Cancer cell Vol. 43; no. 4; pp. 728 - 739.e5
• Main Authors: Lam, W.K. Jacky, Kang, Guannan, Chan, Charles M.L., Lee, Vicky C.T., Ma, Mary-Jane L., Zhou, Qing, Jiang, Peiyong, Tse, Irene O.L., King, Ann D., Wong, Kenneth C.W., Hui, Edwin P., Ma, Brigette B.Y., Chan, Anthony T.C., Chan, K.C. Allen, Lo, Y.M. Dennis
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 14.04.2025
• Subjects: Adult; Aged; cancer screening; Carcinoma; circulating tumor DNA; DNA Methylation; DNA, Viral - blood; DNA, Viral - genetics; Epstein-Barr Virus Infections - blood; Epstein-Barr Virus Infections - complications; Epstein-Barr Virus Infections - virology; Female; Herpesvirus 4, Human - genetics; Humans; liquid biopsy; Male; Middle Aged; Nasopharyngeal Carcinoma; Nasopharyngeal Neoplasms - blood; Nasopharyngeal Neoplasms - diagnosis; Nasopharyngeal Neoplasms - genetics; Nasopharyngeal Neoplasms - virology; Polymerase Chain Reaction; precision oncology; Prospective Studies; risk prediction; precision oncology; cancer screening; risk prediction; liquid biopsy; circulating tumor DNA

Fragmentomics analysis of plasma autosomal DNA has shown promise in cancer diagnostics. Here we evaluated the clinical utility of plasma Epstein-Barr virus (EBV) DNA fragmentomics analysis for nasopharyngeal carcinoma (NPC) screening. Among our prospective cohort of approximately 20,000 subjects tha...