Decreased nitrite levels in erythrocytes of children with β-thalassemia/hemoglobin E

• Published in: Nitric oxide Vol. 33; pp. 1 - 5
• Main Authors: Suvachananonda, Thitiwat, Wankham, Amara, Srihirun, Sirada, Tanratana, Pansakorn, Unchern, Supeenun, Fucharoen, Suthat, Chuansumrit, Ampaiwan, Sirachainan, Nongnuch, Sibmooh, Nathawut
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 01.09.2013
• Subjects: Adolescent; Analysis of Variance; beta-Thalassemia - blood; beta-Thalassemia - drug therapy; beta-Thalassemia - metabolism; Case-Control Studies; Cell-free hemoglobin; Child; Erythrocytes; Female; Hemoglobin E - metabolism; Hemoglobins - metabolism; Humans; Male; Nitric oxide; Nitric Oxide - blood; Nitric Oxide Donors - administration & dosage; Nitric Oxide Donors - pharmacokinetics; Nitrite; Nitrites - blood; Nitroso Compounds - administration & dosage; Nitroso Compounds - pharmacokinetics; Thalassemia; Cell-free hemoglobin; Thalassemia; Nitrite; Nitric oxide; Erythrocytes

•Nitric oxide bioavailability was determined in thalassemia.•Severe thalassemia patients have decreased erythrocytic nitrite levels.•Severe thalassemia patients have increased plasma hemoglobin and NO consumption.•The erythrocytic nitrite correlates with plasma hemoglobin and NO consumption.•Decreas...