Microbiota and metabolite-based prediction tool for colonic polyposis with and without a known genetic driver

• Published in: Gut microbes Vol. 17; no. 1; p. 2474141
• Main Authors: Katona, Bryson W., Shukla, Ashutosh, Hu, Weiming, Nyul, Thomas, Dudzik, Christina, Arvanitis, Alex, Clay, Daniel, Dungan, Michaela, Weber, Marina, Tu, Vincent, Hao, Fuhua, Gan, Shuheng, Chau, Lillian, Buchner, Anna M., Falk, Gary W., Jaffe, David L., Ginsberg, Gregory, Palmer, Suzette N., Zhan, Xiaowei, Patterson, Andrew D., Bittinger, Kyle, Ni, Josephine
• Format: Journal Article
• Language: English
• Published: United States Taylor & Francis 01.12.2025; Taylor & Francis Group
• Subjects: Adult; Aged; alanine; biomarker; Colonic Polyps - genetics; Colonic Polyps - metabolism; Colonic Polyps - microbiology; Colorectal Neoplasms - genetics; Colorectal Neoplasms - metabolism; Colorectal Neoplasms - microbiology; Feces - microbiology; Female; Gastrointestinal Microbiome; Humans; Intestinal Mucosa - microbiology; leucine; Male; Metabolome; microbiome; Middle Aged; Polyposis; Prospective Studies; Research Paper; RNA, Ribosomal, 16S - genetics; leucine; serrated polyposis syndrome; colonic adenomatous polyposis of unknown etiology; alanine; tyrosine; biomarker; Polyposis; microbiome; metabolome

Despite extensive investigations into the microbiome and metabolome changes associated with colon polyps and colorectal cancer (CRC), the microbiome and metabolome profiles of individuals with colonic polyposis, including those with (Gene-pos) and without (Gene-neg) a known genetic driver, remain co...