Monocytes of patients with unstable angina express high levels of chemokine and pattern-recognition receptors

• Published in: Cytokine (Philadelphia, Pa.) Vol. 113; pp. 61 - 67
• Main Authors: Justo-Junior, A.S., Villarejos, L.M., Lima, X.T.V., Nadruz, W., Sposito, A.C., Mamoni, R.L., Abdalla, R., Fernandes, J.L., Oliveira, R.T.D., Blotta, M.H.S.L.
• Format: Journal Article
• Language: English
• Published: England Elsevier Ltd 01.01.2019
• Subjects: Angina, Unstable - metabolism; Atherosclerosis; Chaperonin 60 - metabolism; Chemokines - metabolism; CX3C Chemokine Receptor 1 - metabolism; Female; Heat shock protein 60; Humans; Interleukin-12 - metabolism; Intermediate monocytes; Male; Middle Aged; Monocytes - metabolism; Monocytes subsets; Receptors, CCR2 - metabolism; Receptors, CCR5 - metabolism; Receptors, Pattern Recognition - metabolism; Toll-Like Receptor 2 - metabolism; Toll-Like Receptor 4 - metabolism; Heat shock protein 60; Intermediate monocytes; Monocytes subsets; Atherosclerosis

•The phenotypes of monocyte subsets differ at different stages of atherosclerosis.•UA patients exhibit an increased frequency of chemokine receptors and PRRs.•This increased frequency is seen mainly in intermediate monocytes of UA patients.•HSP60 induces IL-12p70 production in intermediate monocytes...