Synthesis and matched molecular pair analysis of covalent reversible inhibitors of the cysteine protease CPB

• Published in: Bioorganic & medicinal chemistry letters Vol. 30; no. 18; p. 127439
• Main Authors: Matos, Thiago Kelvin Brito, Batista, Pedro Henrique Jatai, dos Reis Rocho, Fernanda, de Vita, Daniela, Pearce, Nicholas, Kellam, Barrie, Montanari, Carlos Alberto, Leitão, Andrei
• Format: Journal Article
• Language: English
• Published: OXFORD Elsevier Ltd 15.09.2020; Elsevier
• Subjects: Additive effect; Chemistry; Chemistry, Medicinal; Chemistry, Organic; Crystallographic structure; Dipeptidyl nitrile derivatives; Enzymatic inhibitors; Life Sciences & Biomedicine; Pharmacology & Pharmacy; Physical Sciences; SAR; Science & Technology; Crystallographic structure; Dipeptidyl nitrile derivatives; Additive effect; Enzymatic inhibitors; SAR; CRUZAIN; CATHEPSIN-K; SUBSITE

[Display omitted] Cysteine protease B (CPB) can be targeted by reversible covalent inhibitors that could serve as antileishmanial compounds. Here, sixteen dipeptidyl nitrile derivatives were synthesized, tested against CPB, and analyzed using matched molecular pairs to determine the effects of stere...