The ADRA2A rs553668 variant is associated with type 2 diabetes and five variants were associated at nominal significance levels in a population-based case–control study from Mexico City

• Published in: Gene Vol. 669; pp. 28 - 34
• Main Authors: Totomoch-Serra, Armando, Muñoz, María de Lourdes, Burgueño, Juan, Revilla-Monsalve, María Cristina, Perez-Muñoz, Ashael, Diaz-Badillo, Álvaro
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier B.V 30.08.2018
• Subjects: Case-Control Studies; Case-control study; Diabetes Mellitus, Type 2 - genetics; Female; Genetic Variation; Humans; Male; Mexico; Mexico City; Middle Aged; Receptors, Adrenergic, alpha-2 - genetics; Single nucleotide variant; Type 2 diabetes; Type 2 diabetes; GWAS; TRG; Case-control study; CHO; ENSANUT; HDL-C; UCP3; HWE; SNV; IGF2BP2; JNC-8; PPARGC1A; BMI; Single nucleotide variant; WHR; T2D; IR; SIRT1; ADRA2A; VEGFA; HOMA-IR; DNA; KCNQ1; TRG/HDL-C; PPARG; FPG; Mexico City

Type 2 diabetes (T2D) is a disease with a prevalence of 9.4% in Mexicans. Its etiology is complex involving environmental and genetic factors. The aim of this study was to analyse the association between PPARG rs1801282, PPARGC1A rs8192678, VEGFA rs2010963, ADRA2A rs553668, KCNQ1 rs2237892, SIRT1 rs...