Impact of Formulation and Suspension Properties on Redispersion of Aluminum-Adjuvanted Vaccines

• Published in: Journal of pharmaceutical sciences Vol. 109; no. 4; pp. 1460 - 1466
• Main Authors: Langford, Alex, Horwitz, Teresa, Adu-Gyamfi, Emmanuel, Wiley, Chris, Holding, Elizabeth, Zimmermann, Daniel, Ignatius, Arun Alphonse, Ohtake, Satoshi
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 01.04.2020
• Subjects: formulation; particle size; physical characterization; physical stability; suspensions; vaccine adjuvants; vaccines; particle size; physical characterization; vaccines; suspensions; formulation; physical stability; vaccine adjuvants

The adsorption of antigens to the surface of 2 commonly used insoluble adjuvants, aluminum phosphate and aluminum hydroxide, has been well characterized. In spite of the pharmaceutical benefits, alum-based vaccine formulations can present challenges in redispersion of the final product after storage...