The inhibitory activity of gallic acid against DNA methylation: application of gallic acid on epigenetic therapy of human cancers

• Published in: Oncotarget Vol. 9; no. 1; pp. 361 - 374
• Main Authors: Weng, Yui-Ping, Hung, Pin-Feng, Ku, Wen-Yen, Chang, Chang-Yuan, Wu, Bo-Han, Wu, Ming-Han, Yao, Jau-Ying, Yang, Ji-Rui, Lee, Chia-Huei
• Format: Journal Article
• Language: English
• Published: United States Impact Journals LLC 02.01.2018
• Subjects: Research Paper; DNA methyltransferase; chemoprevention; gallic acid; post-fermentation oolong tea extract; epigenetics

Epigenome aberrations have been observed in tobacco-associated human malignancies. (-)-epigallocatechin-3-gallate (EGCG) has been proven to modulate gene expression by targeting DNA methyltransferases (DNMTs) through a proposed mechanism involving the gallate moiety of EGCG. We show that gallic acid...