Regulated necrosis in kidney ischemia-reperfusion injury

• Published in: Kidney international Vol. 96; no. 2; pp. 291 - 301
• Main Authors: Pefanis, Aspasia, Ierino, Francesco L., Murphy, James M., Cowan, Peter J.
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 01.08.2019
• Subjects: acute kidney injury; apoptosis; ferroptosis; ischemia-reperfusion injury; kidney transplantation; necroptosis; necrosis; ischemia-reperfusion injury; ferroptosis; necrosis; kidney transplantation; apoptosis; acute kidney injury; necroptosis

Ischemia-reperfusion injury (IRI) is the outcome of an inflammatory process that is triggered when an organ undergoes a transient reduction or cessation of blood flow, followed by re-establishment of perfusion. In the clinical setting, IRI contributes to significant acute kidney injury, patient morb...