Simultaneous determination of abiraterone and its five metabolites in human plasma by LC-MS/MS: Application to pharmacokinetic study in healthy Chinese subjects

• Published in: Journal of pharmaceutical and biomedical analysis Vol. 217; p. 114826
• Main Authors: Hu, Yixin, Wu, Jianyuan, Jiang, Xin, Chen, Guiying, Zhang, Yang, Si, Luqin, Jiang, Hongliang, Huang, Jiangeng, Huang, Jianying
• Format: Journal Article
• Language: English
• Published: England Elsevier B.V 05.08.2022
• Subjects: Abiraterone; LC-MS/MS; Metabolites; Pharmacokinetics; LC-MS/MS; Metabolites; Pharmacokinetics; Abiraterone

In this study, a rapid, simple and sensitive liquid chromatography–tandem mass spectrometry (LC-MS/MS) method was developed and validated to simultaneously quantify abiraterone (ABI), a widely used anti-metastatic castration-resistant prostate cancer drug, and its metabolites comprising Δ4-abiratero...