Genetic analysis of the TBX20 gene promoter region in patients with ventricular septal defects

• Published in: Gene Vol. 500; no. 1; pp. 28 - 31
• Main Authors: Qiao, Yanli, Wanyan, Hongxin, Xing, Qining, Xie, Wen, Pang, Shuchao, Shan, Jiping, Yan, Bo
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier B.V 25.05.2012
• Subjects: Adolescent; Adult; Child; Child, Preschool; Congenital heart disease; Female; Heart Septal Defects, Ventricular - genetics; Humans; Male; Promoter; Promoter Regions, Genetic; Sequence variant; T-Box Domain Proteins - genetics; TBX20; Ventricular septal defect; Young Adult; Gata4/5; Ventricular septal defect; VSD; TOF; Nkx2-5; Congenital heart disease; Tbx; Sequence variant; Promoter; TFAP2; ASD; Mef2C; TBX20; HEK-293; 5’-UTR; CHD; PCR

Congenital heart disease (CHD) is the most common human birth defect. The morbidity and mortality of CHD patients are significantly higher than normal population even after surgical correction of cardiac defects, which is likely caused by genetic defects. To date, genetic causes for CHD remain large...