Molecular classification and clinical diagnosis of acute-on-chronic liver failure patients by serum metabolomics

• Published in: Journal of pharmaceutical and biomedical analysis Vol. 198; p. 114004
• Main Authors: Yu, Meng, Zhou, Chao, Tian, Dong, Jia, Hong-Mei, Li, Zhi-Qing, Yang, Chen, Ba, Yuan-Ming, Wu, Hui-Kun, Zou, Zhong-Mei
• Format: Journal Article
• Language: English
• Published: England Elsevier B.V 10.05.2021
• Subjects: Acute-on-chronic liver failure; Metabolomics; Molecular classification; Molecular diagnosis; UPLC-Q-TOF/MS; CD; Metabolomics; ACLF; RT; Molecular diagnosis; DH; ROC; OPLS-DA; PLS-DA; AUC; PCA; Molecular classification; SD; QC; UPLC-Q-TOF/MS; LPCs; KEGG; Acute-on-chronic liver failure; BPI; ESI; HC; SPSS; TCM

•An UPLC-MS metabolomics method was established to analyze serum metabolome of ACLF patients.•10 serum metabolites as potential biomarkers for diagnosis of ACLF patients.•3 serum metabolites for predicting two types of ACLF patients, i.e. DH and CD. Prevalence of acute-on-chronic liver failure (ACLF...