The IKZF1-IRF4/IRF5 Axis Controls Polarization of Myeloma-Associated Macrophages

• Published in: Cancer immunology research Vol. 9; no. 3; p. 265
• Main Authors: Mougiakakos, Dimitrios, Bach, Christian, Böttcher, Martin, Beier, Fabian, Röhner, Linda, Stoll, Andrej, Rehli, Michael, Gebhard, Claudia, Lischer, Christopher, Eberhardt, Martin, Vera, Julio, Büttner-Herold, Maike, Bitterer, Katrin, Balzer, Heidi, Leffler, Magdalena, Jitschin, Simon, Hundemer, Michael, Awwad, Mohamed H S, Busch, Martin, Stenger, Steffen, Völkl, Simon, Schütz, Christian, Krönke, Jan, Mackensen, Andreas, Bruns, Heiko
• Format: Journal Article
• Language: English
• Published: United States 01.03.2021

The bone marrow niche has a pivotal role in progression, survival, and drug resistance of multiple myeloma cells. Therefore, it is important to develop means for targeting the multiple myeloma bone marrow microenvironment. Myeloma-associated macrophages (MAM) in the bone marrow niche are M2 like. Th...