Population pharmacokinetics of ponesimod and its primary metabolites in healthy and organ-impaired subjects - Lott, Dominik; Krause, Andreas; Dingemanse, Jasper; Lehr, Thorsten (European journal of pharmaceutical sciences, 2016)
Keywords: Adult; Female; Hepatic impairment; Humans; Kidney - drug effects; Kidney - metabolism; Liver - drug effects; Liver - metabolism; Male; Metabolite modeling; Middle Aged; Population pharmacokinetics; Receptors, Lysosphingolipid - metabolism; Renal impairment; S1P1 receptor modulator; Thiazoles - metabolism; Thiazoles - pharmacokinetics; Young Adult; S1P1 receptor modulator; Population pharmacokinetics; Metabolite modeling; Hepatic impairment; Renal impairment; S1P receptor modulator