Immunomodulatory properties and biomarkers characterization of novel Withania somnifera based formulation supplemented with minerals in Sprague Dawley rats
Herbomineral formulations have been accepted world-wide due to its significant therapeutic outcomes. The study aimed to evaluate the immunomodulatory potential of novel herbomineral formulation (TEBEH) on Sprague Dawley rats using cyclophosphamide-induced immunosuppression. Major immune related para...
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| Published in | Advances in traditional medicine (Online) Vol. 17; no. 1; pp. 59 - 69 |
|---|---|
| Main Authors | , , , |
| Format | Journal Article |
| Language | English |
| Published |
Dordrecht
Springer Netherlands
01.03.2017
Spiringer Link 융합한의과학연구소 |
| Subjects | |
| Online Access | Get full text |
| ISSN | 1598-2386 2662-4052 2211-1069 2662-4060 |
| DOI | 10.1007/s13596-016-0255-5 |
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| Abstract | Herbomineral formulations have been accepted world-wide due to its significant therapeutic outcomes. The study aimed to evaluate the immunomodulatory potential of novel herbomineral formulation (TEBEH) on Sprague Dawley rats using cyclophosphamide-induced immunosuppression. Major immune related parameters were monitored such haemagglutination assay, delayed type hypersensitivity reaction, cellular immune response (CD4
+
and CD8
+
), IgG and IgM, hematological analysis, antioxidant profile, and estimation of major lipid biomarkers. The study results suggest herbomineral formulation significantly (
p
≤ 0.05) improved the concentration of primary and secondary titre by 41.18 and 68%. However, the rat paw edema at 24 h showed increased edema by 77.78% (
p
≤ 0.01). Herbomineral formulation exhibited increase in the CD4
+
and CD8
+
counts in animals by 28.03 and 60.70%, respectively. In addition, the concentrations of IgM and IgG were improved by 14.29 and 8.26% respectively. Besides, other supportive parameter such as hematology and antioxidant profile was significantly (
p
≤ 0.001) improved, while free radical, lipid peroxidation was decreased. Moreover, the major lipid biomarkers were improved such as decreased triglycerides, LDL and VLDL by 15.88, 3.65, and 16.01%, respectively. Overall, the promising results of this study indicated that the herbomineral formulation, TEBEH can be employed to improve the cellular and humoral immunity along with improved hematological, antioxidant, and lipid profile.
Graphical abstract |
|---|---|
| AbstractList | Herbomineral formulations have been accepted world-wide due to its significant therapeutic outcomes. The study aimed to evaluate the immunomodulatory potential of novel herbomineral formulation (TEBEH) on Sprague Dawley rats using cyclophosphamide-induced immunosuppression. Major immune related parameters were monitored such haemagglutination assay, delayed type hypersensitivity reaction, cellular immune response (CD4+ and CD8+), IgG and IgM, hematological analysis, antioxidant profile, and estimation of major lipid biomarkers. The study results suggest herbomineral formulation significantly (p ≤ 0.05) improved the concentration of primary and secondary titre by 41.18 and 68%. However, the rat paw edema at 24 h showed increased edema by 77.78% (p ≤ 0.01). Herbomineral formulation exhibited increase in the CD4+ and CD8+ counts in animals by 28.03 and 60.70%, respectively. In addition, the concentrations of IgM and IgG were improved by 14.29 and 8.26% respectively. Besides, other supportive parameter such as hematology and antioxidant profile was significantly (p ≤ 0.001) improved, while free radical, lipid peroxidation was decreased. Moreover, the major lipid biomarkers were improved such as decreased triglycerides, LDL and VLDL by 15.88, 3.65, and 16.01%, respectively. Overall, the promising results of this study indicated that the herbomineral formulation, TEBEH can be employed to improve the cellular and humoral immunity along with improved hematological, antioxidant, and lipid profile. KCI Citation Count: 0 Herbomineral formulations have been accepted world-wide due to its significant therapeutic outcomes. The study aimed to evaluate the immunomodulatory potential of novel herbomineral formulation (TEBEH) on Sprague Dawley rats using cyclophosphamide-induced immunosuppression. Major immune related parameters were monitored such haemagglutination assay, delayed type hypersensitivity reaction, cellular immune response (CD4 + and CD8 + ), IgG and IgM, hematological analysis, antioxidant profile, and estimation of major lipid biomarkers. The study results suggest herbomineral formulation significantly ( p ≤ 0.05) improved the concentration of primary and secondary titre by 41.18 and 68%. However, the rat paw edema at 24 h showed increased edema by 77.78% ( p ≤ 0.01). Herbomineral formulation exhibited increase in the CD4 + and CD8 + counts in animals by 28.03 and 60.70%, respectively. In addition, the concentrations of IgM and IgG were improved by 14.29 and 8.26% respectively. Besides, other supportive parameter such as hematology and antioxidant profile was significantly ( p ≤ 0.001) improved, while free radical, lipid peroxidation was decreased. Moreover, the major lipid biomarkers were improved such as decreased triglycerides, LDL and VLDL by 15.88, 3.65, and 16.01%, respectively. Overall, the promising results of this study indicated that the herbomineral formulation, TEBEH can be employed to improve the cellular and humoral immunity along with improved hematological, antioxidant, and lipid profile. Graphical abstract Herbomineral formulations have been accepted world-wide due to its significant therapeutic outcomes. The study aimed to evaluate the immunomodulatory potential of novel herbomineral formulation (TEBEH) on Sprague Dawley rats using cyclophosphamide-induced immunosuppression. Major immune related parameters were monitored such haemagglutination assay, delayed type hypersensitivity reaction, cellular immune response (CD4+ and CD8+), IgG and IgM, hematological analysis, antioxidant profile, and estimation of major lipid biomarkers. The study results suggest herbomineral formulation significantly (p ≤ 0.05) improved the concentration of primary and secondary titre by 41.18 and 68%. However, the rat paw edema at 24 h showed increased edema by 77.78% (p ≤ 0.01). Herbomineral formulation exhibited increase in the CD4+ and CD8+ counts in animals by 28.03 and 60.70%, respectively. In addition, the concentrations of IgM and IgG were improved by 14.29 and 8.26% respectively. Besides, other supportive parameter such as hematology and antioxidant profile was significantly (p ≤ 0.001) improved, while free radical, lipid peroxidation was decreased. Moreover, the major lipid biomarkers were improved such as decreased triglycerides, LDL and VLDL by 15.88, 3.65, and 16.01%, respectively. Overall, the promising results of this study indicated that the herbomineral formulation, TEBEH can be employed to improve the cellular and humoral immunity along with improved hematological, antioxidant, and lipid profile. |
| Author | Jana, Snehasis Trivedi, Mahendra Kumar Gangwar, Mayank Mondal, Sambhu Charan |
| Author_xml | – sequence: 1 givenname: Mahendra Kumar surname: Trivedi fullname: Trivedi, Mahendra Kumar organization: Trivedi Global, Inc – sequence: 2 givenname: Mayank surname: Gangwar fullname: Gangwar, Mayank organization: Trivedi Science Research Laboratory Pvt. Ltd – sequence: 3 givenname: Sambhu Charan surname: Mondal fullname: Mondal, Sambhu Charan organization: Trivedi Science Research Laboratory Pvt. Ltd – sequence: 4 givenname: Snehasis surname: Jana fullname: Jana, Snehasis email: jana@trivedisrl.com organization: Trivedi Science Research Laboratory Pvt. Ltd |
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| Cites_doi | 10.4103/0971-5916.154510 10.4103/0974-8520.77164 10.1023/A:1005502632053 10.5567/pharmacologia.2015.168.177 10.1155/2012/754250 10.1016/j.intimp.2006.04.001 10.4103/0975-1483.80296 10.1016/j.disamonth.2006.05.005 10.1016/0006-291X(87)91297-6 10.1016/j.phytochem.2010.04.001 10.1097/00007611-200194120-00014 10.1016/j.jep.2014.06.051 10.1038/icb.1967.9 10.14202/vetworld.2014.1075-1081 10.1080/15476910701337357 10.1016/0003-2697(72)90132-7 10.1111/j.1432-1033.1974.tb03714.x 10.1016/j.foodchem.2008.06.013 10.4103/0975-9476.104444 10.14202/vetworld.2015.1156-1162 10.5539/ijb.v3n2p3 10.1089/acm.2008.0215 10.1007/s00018-015-2012-1 10.1016/0378-8741(95)01318-0 10.1016/j.lfs.2007.01.029 10.1039/c0np00045k 10.1016/S0367-326X(99)00031-3 10.1093/ecam/nel101 10.1002/cbdv.201600280 |
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| Keywords | Lipid profile Herbomineral product Immunopotentiation Hematological parameters Antioxidant profile Cellular and humoral immunity |
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| Title | Immunomodulatory properties and biomarkers characterization of novel Withania somnifera based formulation supplemented with minerals in Sprague Dawley rats |
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