The importance of surface composition and wettability on the dissolution performance of high drug loading amorphous dispersion formulations - Hiew, Tze Ning; Solomos, Marina A.; Kafle, Prapti; Polyzois, Hector; Zemlyanov, Dmitry Y.; Punia, Ashish; Smith, Daniel; Schenck, Luke; Taylor, Lynne S. (Journal of pharmaceutical sciences, 2025)
Keywords: Amorphous solid dispersion; Chemistry, Pharmaceutical - methods; Co-precipitated amorphous dispersion; Co-precipitation; Drug Compounding - methods; Drug Liberation; Excipients - chemistry; Grazoprevir; Hierarchical; Hydrophobic and Hydrophilic Interactions; Hypromellose Derivatives - chemistry; Particle Size; Particle wettability; Solubility; Sulfonamides - chemistry; Surface Properties; Wettability; Co-precipitated amorphous dispersion; Hierarchical; Amorphous solid dispersion; Particle wettability; Co-precipitation; Grazoprevir