Assessment of blood-brain barrier integrity and neuroinflammation in preeclampsia

• Published in: American journal of obstetrics and gynecology Vol. 221; no. 3; pp. 269.e1 - 269.e8
• Main Authors: Burwick, Richard M., Togioka, Brandon M., Speranza, Rosa J., Gaffney, Jessica E., Roberts, Victoria H.J., Frias, Antonio E., Rincón, Mónica
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 01.09.2019
• Subjects: Adult; albumin; Albumins - metabolism; Biomarkers - metabolism; Blood-Brain Barrier; brain; Case-Control Studies; central nervous system; cerebrospinal fluid; complement proteins; Complement System Proteins - metabolism; cytokines; Cytokines - metabolism; Female; Humans; hypertension; Inflammation - metabolism; neuroinflammation; Pre-Eclampsia - metabolism; Pre-Eclampsia - physiopathology; preeclampsia; Pregnancy; complement proteins; neuroinflammation; albumin; cerebrospinal fluid; pregnancy; cytokines; preeclampsia; brain; hypertension; central nervous system

Although blood-brain barrier integrity is intact under normal pregnancy conditions, animal studies suggest that blood-brain barrier impairment occurs in preeclampsia. Yet, human data are limited, and the integrity of the blood-brain barrier has not been assessed in women with preeclampsia. We sought...