Genetic interactions between the hedgehog co-receptors Gas1 and Boc regulate cell proliferation during murine palatogenesis

• Published in: Oncotarget Vol. 7; no. 48; pp. 79233 - 79246
• Main Authors: Xavier, Guilherme M, Seppala, Maisa, Papageorgiou, Spyridon N, Fan, Chen-Ming, Cobourne, Martyn T
• Format: Journal Article
• Language: English
• Published: United States Impact Journals LLC 29.11.2016
• Subjects: Animals; Cell Cycle; Cell Cycle Proteins - genetics; Cell Cycle Proteins - metabolism; Cell Proliferation; Cells, Cultured; Gene Expression Regulation, Developmental; GPI-Linked Proteins - genetics; GPI-Linked Proteins - metabolism; Hedgehog Proteins - metabolism; Immunoglobulin G - genetics; Immunoglobulin G - metabolism; Mesenchymal Stromal Cells - cytology; Mice; Mutation; Palate - growth & development; Palate - metabolism; Receptors, Cell Surface - genetics; Receptors, Cell Surface - metabolism; Research Paper; Signal Transduction; palatogenesis; Gas1; cleft palate; Shh signaling; Boc

Abnormal regulation of Sonic hedgehog (Shh) signaling has been described in a variety of human cancers and developmental anomalies, which highlights the essential role of this signaling molecule in cell cycle regulation and embryonic development. Gas1 and Boc are membrane co-receptors for Shh, which...