Validated HILIC–MS/MS assay for determination of vindesine in human plasma: Application to a population pharmacokinetic study

• Published in: Journal of pharmaceutical and biomedical analysis Vol. 96; pp. 31 - 36
• Main Authors: Zhu, Rong-Hua, Li, Huan-De, Cai, Hua-Lin, Jiang, Zhi-Ping, Xu, Ping, Dai, Li-Bo, Peng, Wen-Xing
• Format: Journal Article
• Language: English
• Published: England Elsevier B.V 05.08.2014
• Subjects: Adult; Antineoplastic Agents, Phytogenic - pharmacokinetics; Antineoplastic Agents, Phytogenic - therapeutic use; Calibration; Chromatography, High Pressure Liquid - methods; Female; Hematologic Neoplasms - drug therapy; HILIC; Humans; Limit of Detection; Male; Middle Aged; MS/MS; Pharmacokinetics; Reference Standards; Reproducibility of Results; Solid Phase Extraction; Spectrometry, Mass, Electrospray Ionization - methods; Tandem Mass Spectrometry - methods; Vinblastine - analogs & derivatives; Vinblastine - chemistry; Vindesine; Vindesine - pharmacokinetics; Vindesine - therapeutic use; Vinorelbine; Young Adult; MS/MS; Pharmacokinetics; HILIC; Vindesine; Vinorelbine

Mean plasma concentration–time profiles of intravenous injection of 3mg Vindesine Sulfate for Injection to 100 unrelated Chinese Han subjects with hematological malignant disorders. •HILIC separation mode coupled to ESI-MS/MS was used for quantitative analysis.•The analytes of interest were well sep...