Anti-cancer activity of Annexin V in murine melanoma model by suppressing tumor angiogenesis
Annexin V, a protein with high affinity to phosphatidylserine (PS) in a calcium dependent manner, has been widely used to probe apoptosis. Annexin V in inhibiting engulfment of apoptotic cells by macrophages had been reported to increase the immunogenicity of tumor cells undergoing apoptosis. Howeve...
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Published in | Oncotarget Vol. 8; no. 26; pp. 42602 - 42612 |
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Main Authors | , , , , , , , , , |
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Abstract | Annexin V, a protein with high affinity to phosphatidylserine (PS) in a calcium dependent manner, has been widely used to probe apoptosis. Annexin V in inhibiting engulfment of apoptotic cells by macrophages had been reported to increase the immunogenicity of tumor cells undergoing apoptosis. However, far less is known about its multiple properties, especially in cancer therapies. Here we found that Annexin V had a good anti-tumor activity in murine melanomaxenograft model. Treatment with Annexin V showed significant reduction in tumor size and remarkable tumor necrosis areas. The serum level of VEGF was downregualted by Annexin V both in normal mice and mice bearing tumor, suggesting that its new role on impeding tumor angiogenesis. In Silico analysis using Oncomine database, we also found the negative correlation of AnnexinV and VEGF both in skin and melanoma. The decreased Annexin V expression shows linearity relation with the elevated VEGF expression. These data provided a possibility that Annexin V can be used as a novel angiogenesis inhibitor in tumor therapy. |
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AbstractList | Annexin V, a protein with high affinity to phosphatidylserine (PS) in a calcium dependent manner, has been widely used to probe apoptosis. Annexin V in inhibiting engulfment of apoptotic cells by macrophages had been reported to increase the immunogenicity of tumor cells undergoing apoptosis. However, far less is known about its multiple properties, especially in cancer therapies. Here we found that Annexin V had a good anti-tumor activity in murine melanomaxenograft model. Treatment with Annexin V showed significant reduction in tumor size and remarkable tumor necrosis areas. The serum level of VEGF was downregualted by Annexin V both in normal mice and mice bearing tumor, suggesting that its new role on impeding tumor angiogenesis. In Silico analysis using Oncomine database, we also found the negative correlation of AnnexinV and VEGF both in skin and melanoma. The decreased Annexin V expression shows linearity relation with the elevated VEGF expression. These data provided a possibility that Annexin V can be used as a novel angiogenesis inhibitor in tumor therapy. Annexin V, a protein with high affinity to phosphatidylserine (PS) in a calcium dependent manner, has been widely used to probe apoptosis. Annexin V in inhibiting engulfment of apoptotic cells by macrophages had been reported to increase the immunogenicity of tumor cells undergoing apoptosis. However, far less is known about its multiple properties, especially in cancer therapies. Here we found that Annexin V had a good anti-tumor activity in murine melanomaxenograft model. Treatment with Annexin V showed significant reduction in tumor size and remarkable tumor necrosis areas. The serum level of VEGF was downregualted by Annexin V both in normal mice and mice bearing tumor, suggesting that its new role on impeding tumor angiogenesis. In Silico analysis using Oncomine database, we also found the negative correlation of AnnexinV and VEGF both in skin and melanoma. The decreased Annexin V expression shows linearity relation with the elevated VEGF expression. These data provided a possibility that Annexin V can be used as a novel angiogenesis inhibitor in tumor therapy. |
Author | Zhang, Jing Han, Yuheng Zhang, Yanjun Hua, Zichun Jin, Haibo Le, Ziwei Lai, Xinghuan Zhang, Xuerui Huo, Lina Wang, Jie |
AuthorAffiliation | 2 Changzhou High-Tech Research Institute of Nanjing University and Jiangsu Target Pharma Laboratories Inc., Changzhou 213164, Jiangsu, China 1 The State Key Laboratory of Pharmaceutical Biotechnology, School of Life Science, Nanjing University, Nanjing 210093, Jiangsu, China 3 The State Key Laboratory of Natural Medicines, China Pharmaceutical University, Nanjing 210009, Jiangsu, China |
AuthorAffiliation_xml | – name: 2 Changzhou High-Tech Research Institute of Nanjing University and Jiangsu Target Pharma Laboratories Inc., Changzhou 213164, Jiangsu, China – name: 3 The State Key Laboratory of Natural Medicines, China Pharmaceutical University, Nanjing 210009, Jiangsu, China – name: 1 The State Key Laboratory of Pharmaceutical Biotechnology, School of Life Science, Nanjing University, Nanjing 210093, Jiangsu, China |
Author_xml | – sequence: 1 givenname: Xuerui surname: Zhang fullname: Zhang, Xuerui organization: Changzhou High-Tech Research Institute of Nanjing University and Jiangsu Target Pharma Laboratories Inc., Changzhou 213164, Jiangsu, China – sequence: 2 givenname: Lina surname: Huo fullname: Huo, Lina organization: The State Key Laboratory of Pharmaceutical Biotechnology, School of Life Science, Nanjing University, Nanjing 210093, Jiangsu, China – sequence: 3 givenname: Haibo surname: Jin fullname: Jin, Haibo organization: The State Key Laboratory of Pharmaceutical Biotechnology, School of Life Science, Nanjing University, Nanjing 210093, Jiangsu, China – sequence: 4 givenname: Yuheng surname: Han fullname: Han, Yuheng organization: The State Key Laboratory of Pharmaceutical Biotechnology, School of Life Science, Nanjing University, Nanjing 210093, Jiangsu, China – sequence: 5 givenname: Jie surname: Wang fullname: Wang, Jie organization: The State Key Laboratory of Pharmaceutical Biotechnology, School of Life Science, Nanjing University, Nanjing 210093, Jiangsu, China – sequence: 6 givenname: Yanjun surname: Zhang fullname: Zhang, Yanjun organization: The State Key Laboratory of Pharmaceutical Biotechnology, School of Life Science, Nanjing University, Nanjing 210093, Jiangsu, China – sequence: 7 givenname: Xinghuan surname: Lai fullname: Lai, Xinghuan organization: The State Key Laboratory of Pharmaceutical Biotechnology, School of Life Science, Nanjing University, Nanjing 210093, Jiangsu, China – sequence: 8 givenname: Ziwei surname: Le fullname: Le, Ziwei organization: The State Key Laboratory of Pharmaceutical Biotechnology, School of Life Science, Nanjing University, Nanjing 210093, Jiangsu, China – sequence: 9 givenname: Jing surname: Zhang fullname: Zhang, Jing organization: The State Key Laboratory of Pharmaceutical Biotechnology, School of Life Science, Nanjing University, Nanjing 210093, Jiangsu, China – sequence: 10 givenname: Zichun surname: Hua fullname: Hua, Zichun organization: The State Key Laboratory of Natural Medicines, China Pharmaceutical University, Nanjing 210009, Jiangsu, China |
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Cites_doi | 10.1016/S0360-3016(02)03928-7 10.1038/srep03565 10.1136/gutjnl-2012-302529 10.1016/j.yexcr.2005.11.023 10.4049/jimmunol.148.7.2207 10.1152/ajpcell.00340.2011 10.1111/j.1349-7006.2011.02147.x 10.1158/1078-0432.CCR-07-1516 10.2174/092986707779941131 10.1080/10826060008544969 10.1152/physrev.00030.2001 10.1055/s-2005-872438 10.1080/08916930902832041 10.1016/S0049-3848(10)70031-1 10.1016/j.bbamem.2011.07.026 10.1158/0008-5472.CAN-08-2281 10.1158/0008-5472.CAN-05-3000 10.2174/1566524033479465 10.1080/08916930701357331 10.1046/j.1365-2141.1999.01718.x 10.1016/j.canlet.2009.03.041 10.1084/jem.20040327 10.1073/pnas.0804543106 10.1038/nri2216 10.1182/blood-2009-10-249607 |
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Keywords | apoptosis Annexin V necrosis tumor angiogenesis |
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SubjectTerms | Animals Annexin A5 - pharmacology Apoptosis - drug effects Disease Models, Animal Female Melanoma, Experimental - blood supply Melanoma, Experimental - drug therapy Melanoma, Experimental - pathology Mice Mice, Inbred C57BL Neovascularization, Pathologic - drug therapy Neovascularization, Pathologic - pathology Random Allocation Research Paper |
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Title | Anti-cancer activity of Annexin V in murine melanoma model by suppressing tumor angiogenesis |
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